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Rat Astrocytes-adult (RA-a)

Rat Astrocytes-adult (RA-a)

Catalog Number: 10RA-006
Availability: In Stock
Price: $339.00

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Product Description

Astrocytes are the most abundant cell type in the central nervous system (CNS) and they provide a variety of vital functions for the CNS including: establishment and regulation of the blood brain barrier, functional support for neuronal transmission, survival of neurons, anti-inflammatory responses and wound repair [1]. Astrocytes have also been implicated in various pathological processes such as reactive gliosis [2]. Impairment of normal astrocyte functions during stroke and other insults can critically influence neuron survival. Long-term recovery after brain injury, through neurite outgrowth, synaptic plasticity, or neuron regeneration, is also influenced by astrocyte surface molecule expression and trophic factor release [3]. Numerous studies have demonstrated that astrocytes are among the most functionally diverse group of cells in the CNS [4]. Rat astrocytes-adult (RA-a) are a useful in vitro model for studying adult glial function and the molecular mechanisms of CNS diseases such as ischemic stroke and multiple sclerosis.

iXCells Biotechnologies provides high quality Rat Astrocytes-adult (RA-a), which are isolated from adult rat brain and cryopreserved at P1, with >0.5 million cells in each vial. RA-a express GFAP and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for 5 population doublings in  Astrocyte Growth Medium-rodent (Cat# MD-0060) under the condition suggested by iXCells Biotechnologies.

Product Details

  Tissue

  Adult rat brain

  Package Size

  0.5x106 cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Astrocyte Growth Medium-rodent (Cat# MD-0060)

References

[1] Rudge JS. (1993) "Astrocyte-derived neurotrophic factors." In Murphy S, Astrocytes: Pharmacology and Function (pp 267-94). San Diego: Academic Press, Inc.
[2] van der Laan LJ, De Groot CJ, Elices MJ, Dijkstra CD. (1997) "Extracellular matrix proteins expressed by human adult astrocytes in vivo and in vitro: an astrocyte surface protein containing the CS1 domain contributes to binding of lymphoblasts." J Neurosci Res. 50: 539-48. 
[3] Chen Y, Swanson RA. (2003) "Astrocytes and brain injury." J Cereb Blood Flow Metab. 23: 137-49.
[4] Shao Y, McCarhy KD. (1994) "Plasticity of astrocytes." Glia. 11: 147-55.

Download Datasheet

[1] Rudge JS. (1993) "Astrocyte-derived neurotrophic factors." In Murphy S, Astrocytes: Pharmacology and Function (pp 267-94). San Diego: Academic Press, Inc.
[2] van der Laan LJ, De Groot CJ, Elices MJ, Dijkstra CD. (1997) "Extracellular matrix proteins expressed by human adult astrocytes in vivo and in vitro: an astrocyte surface protein containing the CS1 domain contributes to binding of lymphoblasts." J Neurosci Res. 50: 539-48. 
[3] Chen Y, Swanson RA. (2003) "Astrocytes and brain injury." J Cereb Blood Flow Metab. 23: 137-49.
[4] Shao Y, McCarhy KD. (1994) "Plasticity of astrocytes." Glia. 11: 147-55.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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