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Recombinant Human 4-1BB Receptor (TNFRSF9)

Catalog Number: IX101085
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Price: $147.00

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Alternative Names Tumor necrosis factor receptor superfamily member 9, 41BB, 4-1BB ligand receptor, CDw137, T-cell antigen 4-1BB homolog, T-cell antigen ILA, CD137
Recombinant Human 4-1BB (TNFRSF9)
Description 4-1BB Receptor (CD137) is a member of the TNF receptor superfamily expressed on activated CD4 and CD8 T cells as well as on activated natural killer cells. The binding of 4-1BB Receptor to its TNF family ligand, 4-1BB ligand (4-1BBL) delivers a co-stimulatory signal to resting T cells leading to high level IL2 production independently of CD28 signaling. Recombinant Human 4-1BB Receptor represents the soluble, cysteine-rich TNFR-like extracellular domain of 4-1BB Receptor.
Gene Symbol TNFRSF9
Gene ID 3604
Accession No. Q07011
Source E. coli
Appearance Lyophilized Powder
Molecular Weight 18.0 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method
Purity >95% as determined by SDS-PAGE
Gel Image Click To Enlarge
Bioactivity The ED50 as determined by dose dependent proliferation of human megakaryocytic leukemia cell line is <0.5ng/ml.
Bioactivity Data Click To Enlarge
Formulation Lyophilized from 0.2 μm filtered solution in PBS (pH 7.5)
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage Recombinant 4-1BB Receptor can be stored in working aliquots at 2° - 8°C for one month, or at -20°C to -70°C for twelve months. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.