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Recombinant Human ABL2 (N-His tag)

Catalog Number: IX500002
Availability: In Stock
Price: $371.70

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Alternative Names ARG; ABLL
Description ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas . Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments . 
Gene Symbol ABL2
Accession No. NM_005158
Source Insect cells
Appearance Liquid
Molecular Weight 132.0 kDa
Purity 70% - 90%
Bioactivity The specific activity of ABL2 was determined tobe 1218 nmol/min/mg as per activity assay protocol
Formulation 50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol.
Storage Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.