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Recombinant Human AIMP1

Catalog Number: IX100155
Availability: In Stock
Price: $147.00

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Alternative Names EMAP II, EMAP-2, Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, Small inducible cytokine subfamily E member 1, SCYE1
Recombinant Human Endothelial Monocyte-Activating Polypeptide 2 (AIMP1)
Description EMAP-II is activated during apoptosis by cleavage of pro-EMAP through caspase 8 and enhances the recruitment of inflammatory cells by its chemotactic properties. Besides its chemotactic effect on inflammatory cells, EMAP-II increases the adhesiveness of coronary artery smooth muscle cells (CASMC) for monocytes. EMAP-II also has anti-angiogenic properties, which are explained by its pro-apoptotic effect on endothelial cells.
Gene Symbol AIMP1
Gene ID 9255
Accession No. Q12904
Source E. coli
Appearance Lyophilized Powder
Molecular Weight 18.0 kDa
Endotoxin Level <1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity >95% as determined by SDS-PAGE
Bioactivity The ED(50) was determined by apoptotic effect on MCF-7 cells using a concentration of 10-50 ng/mL.
Formulation Recombinant EMAP-II was lyophilized from a 0.2 μm filtered 20 mM PB,130 mM NaCl solution pH 7.5.
Reconstitution A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Usage For research use only. Not for diagnostic or therapeutic use.