Activation-inducible TNF-related ligand, AITRL, Glucocorticoid-induced TNF-related ligand, GITRL, hGITRL, Tumor necrosis factor ligand superfamily member 18, TNFSF18, TL-6
Recombinant Human Activation-Induced TNFR Member Ligand (TNFSF18)
TNFSF18 is a transmembrane glycoprotein which is expressed in vascular endothelial cells as well as neurons, antigen presenting cells, CD4Â-CD8Â double negative thymic precursors, and in the eye. TNFSF18 works to mediate the interactions between T cells and endothelial cells, and T cell growth. It has been shown that TNFSF18's expression is transiently up-regulated by proinflammatory stimulation.
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
>95% as determined by SDS-PAGE
Lyophilized from a 0.2 micron filtered solution in Tris and salt
Reconstitute at 0.1 mg/mL in PBS containing at least 0.1% human or bovine serum albumin.
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
For research use only. Not for diagnostic or therapeutic use.