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Human Adipose Microvascular Endothelial Cells (HAMEC)

Human Adipose Microvascular Endothelial Cells (HAMEC)

Catalog Number: 10HU-047
Availability: In Stock
Price: $659.00

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Product Description

Microvascular endothelial cells line blood vessels and contribute to many biological processes such as angiogenesis, coagulation, trafficking of lymphocytes, and the inflammatory response. Microvascular endothelial cells are diverse and have specific cellular characteristics and functions depending on the organ/tissue in which they are located. Adipose tissue is unique because it has the capacity to continually grow throughout adult life. Thus, it has a high level of angiogenesis to provide the extensive vascularization required for adipose tissue [1]. Studies have shown that angiogenesis precedes adipogenesis, implying that microvascular endothelial cells influence the proliferation of preadipocytes [2]. At the same time, microvascular endothelial cell growth is stimulated by adipocyte secreted VEGG, suggesting a complex paracrine relationship between microvascular endothelial cells and preadipocytes during tissue development [3].

HAMEC from iXCells Biotechnologies are isolated from human adipose tissue. HAMEC are cryopreserved and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HAMEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM) and by uptake of DiI-Ac-LDL. HAMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAMEC are guaranteed to further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010).

Product Details

  Tissue

  Human adipose tissue

  Package Size

  0.5 million cells/vial  

  Passage Number

  P2

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Crandall D.L., Hausman G.J., Kral J.G. (1997) A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4(2):211-32
[2] Hutley, L. J., Herington, A. C., Shurety, W., Cheung, C., Vesey, D. A., Cameron, D. P., Prins, J. B. (2000) Human adipose tissue endothelial cells promote preadipocyte proliferation. American Journal of Physiology: Endocrinology and Metabolism. 281(5):E1037-E1044
[3] Hausman, G. J., Richardson, R. L. (2004) Adipose tissue angiogenesis. Journal of Animal Science. 82(3): 925-934

[1] Crandall D.L., Hausman G.J., Kral J.G. (1997) A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation 4(2):211-32
[2] Hutley, L. J., Herington, A. C., Shurety, W., Cheung, C., Vesey, D. A., Cameron, D. P., Prins, J. B. (2000) Human adipose tissue endothelial cells promote preadipocyte proliferation. American Journal of Physiology: Endocrinology and Metabolism. 281(5):E1037-E1044
[3] Hausman, G. J., Richardson, R. L. (2004) Adipose tissue angiogenesis. Journal of Animal Science. 82(3): 925-934

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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