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Human Adrenal Microvascular Endothelial Cells (HAdMEC)

Human Adrenal Microvascular Endothelial Cells (HAdMEC)

Catalog Number: 10HU-048
Availability: Out Of Stock
Price: $619.00

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Product Description

The adrenal gland plays an essential role in regulating homeostasis in the body through the secretion of corticosteroid and androgen hormones. The secreted steroids arise from the three zones of the adrenal gland: the zona glomerulosa, zona fasciculate, and zona reticularis. Microvascular endothelial cells (MEC) line the blood vessels and contribute to many biological processes such as hemostasis, coagulation, trafficking of lymphocytes, and the inflammatory response. MEC regulate the secretion of adrenal hormones in the adrenal gland [1]. Studies have shown that factors secreted from HAdMEC, such as endothelin-1, nitric oxide, adrenomedullin and proadrenomedullin NH2-terminal 20 peptide affect aldosterone secretion [1]. HAdMEC, unlike brain and liver MECs, are highly resistant to glucocorticoid-induced cytotoxicity [2]. 

HAdMEC from iXCells Biotechnologies are isolated from human adrenal tissue. HAdMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HAdMEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM). HAdMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAdMEC are guaranteed to further culture for 12 population doublings  in Endothelial Cell Growth Medium (Cat# MD-0010).

Product Details

  Tissue

  Human adrenal tissue

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Hinson, J.P., Kapas, S. 1998. The role of endothelial cell product in the regulation of adrenocortical functions: actions of endothelin, nitric oxide, adrenomedullin and PAMP. Horm Metab Res. 30(6-7): 334-40
[2] Gu, F., Zhang, WJ., Wu, LQ., Ye, LY., Li, HZ., Li, J., Xu, SQ., XU, YP., Lou, JN. 2006. Characteristics of human adrenal microvascular endothelial cells in morphology, phenotypes, and function. Ahonqquo Yi Xue Ke Xue Yuan Xue Bao. 28(4):502-6

[1] Hinson, J.P., Kapas, S. 1998. The role of endothelial cell product in the regulation of adrenocortical functions: actions of endothelin, nitric oxide, adrenomedullin and PAMP. Horm Metab Res. 30(6-7): 334-40
[2] Gu, F., Zhang, WJ., Wu, LQ., Ye, LY., Li, HZ., Li, J., Xu, SQ., XU, YP., Lou, JN. 2006. Characteristics of human adrenal microvascular endothelial cells in morphology, phenotypes, and function. Ahonqquo Yi Xue Ke Xue Yuan Xue Bao. 28(4):502-6

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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