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Human Cardiac Microvascular Endothelial Cells (HCMEC)

Human Cardiac Microvascular Endothelial Cells (HCMEC)

Catalog Number: 10HU-052
Availability: In Stock
Price: $549.00

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Product Description

The endothelial cells modulate vascular tone by release of several endothelium-derived contracting and relaxing factors, by regulation and degradation of vasoactive peptides, and by enzymes located on the Cardiac microvascular endothelial cells (HCMEC) play important roles in myocardial function. HCMEC regulate vascular tone by releasing and degrading endothelium-derived vasoactive factors, and modulating the local levels of vasoconstrictors and vasodilators through their enzymatic activities. Many of these substances can also modify myocardial contractile behavior [1]. Furthermore, microvasculature has been shown to participate in the regulation of leukocyte recruitment, inflammation, and angiogenesis. They are also capable of trans-differentiating into myofibroblasts, suggesting a role in aberrant accumulation of matrix and fibrotic disorders [2]. HCMEC cultures provide an invaluable tool for understanding HCMEC physiological and pathophysiological relevance in cardiac function and disease. 

HCMEC from iXCells Biotechnologies are isolated from human heart. HCMEC are cryopreserved after purification and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HCMEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM), and by uptake of DiI-Ac-LDL. HCMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HCMEC are guaranteed to further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010).

Product Details

  Tissue

  Human heart

  Package Size

  0.5 million cells/vial  

  Passage Number

  P2

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Yang, Z. K., Draper, N. J. and Shah, A. M. (1999) Ca2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts. Am. J. Physiol. 276:H623-632.
[2] Paulus, W. J., P. J. Vantrimpont, and A. M. Shah. Paracrine coronary endothelial control of left ventricular function in humans. Circulation 92: 2119-2162, 1995 
[3] Shah, A. M. (1996) Paracrine modulation of heart cell function by endothelial cells. Cardiovasc Res, 31(6):847-67.

[1] Yang, Z. K., Draper, N. J. and Shah, A. M. (1999) Ca2+-independent inhibition of myocardial contraction by coronary effluent of hypoxic rat hearts. Am. J. Physiol. 276:H623-632.
[2] Paulus, W. J., P. J. Vantrimpont, and A. M. Shah. Paracrine coronary endothelial control of left ventricular function in humans. Circulation 92: 2119-2162, 1995 
[3] Shah, A. M. (1996) Paracrine modulation of heart cell function by endothelial cells. Cardiovasc Res, 31(6):847-67.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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