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Human Chondrocytes - Osteoarthritis (HC-oa)

Human Chondrocytes - Osteoarthritis (HC-oa)

Catalog Number: 10HU-044
Availability: Out Of Stock
Price: $719.00

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Product Description

HC-oa Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis.  Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix.  Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage.  Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development.  Thus, HC-o provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the osteoarthritis  joint.  

iXCells Biotechnologies provides high quality Human Chondrocytes-Osteoarthritis (HC-oa), which are isolated from human articular cartilage of donors with osteoarthritis and cryopreserved at P1, with >0.5 million cells in each vial. These HC-oa are positive for aggrecan after differentiation and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HC-oa can further expand for 10 population doublings in Chondrocyte Medium (Cat# MD-0040) under the condition suggested by iXCells Biotechnologies.

Product Details

  Tissue

  Human articular cartilage of donors with osteoarthritis

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Chondrocyte Medium  (Cat# MD-0040)

References

[1] Xue, J., J. Wang, Q. Liu, and A. Luo. 2013. Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes. Molecular medicine reports: 10.3892/mmr.2013.1729.
2005
[2] Quintavalla, J., C. Kumar, S. Daouti, E. Slosberg, and S. Uziel-Fusi. 2005. Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis. Journal of cellular physiology. 204:560-566.

[1] Xue, J., J. Wang, Q. Liu, and A. Luo. 2013. Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes. Molecular medicine reports: 10.3892/mmr.2013.1729.
2005
[2] Quintavalla, J., C. Kumar, S. Daouti, E. Slosberg, and S. Uziel-Fusi. 2005. Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis. Journal of cellular physiology. 204:560-566.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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