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Human Choroid Plexus Epithelial Cells (HCPEpC)

Human Choroid Plexus Epithelial Cells (HCPEpC)

Catalog Number: 10HU-095
Availability: Out Of Stock
Price: $699.00

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Product Description

The choroid plexus is located in the ventricles of the brain where cerebrospinal fluid (CSF) is constantly produced. It consists of a network of capillaries enclosed by a single layer of epithelial cells that together form the blood-CSF barrier [1]. Human choroid plexus epithelial cells (HCPEpC) play a central role in restricting the passage of molecules and ions between the brain and CSF by the junctional complexes between neighboring cells. They also have a special cellular structure, and channel and transporter protein expression well-adapted for CSF secretion [2]. A previous study further demonstrated that HCPEpCrespond to ischemic and traumatic insults in the central nervous system by synthesizing and secreting various growth factors and peptides with trophic benefits that work through autocrine and paracrine mechanisms to facilitate recovery [3]. HCPEpCcultures serve as an excellent model to study the exchange processes across blood-CSF barrier, CSF homeostasis, and more.

HCPEpC from iXCells Biotechnologies are isolated from human choroid plexus. HCPEpC are cryopreserved after purification and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HCPEpC are characterized by immunofluorescence with antibodies specific to cytokeratin-18, -19 and vimentin. HCPEpC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HCPEpC are guaranteed to further expand for 5 population doublings in Epithelial Cell Growth Medium (Cat# MD-0041).

Product Details

  Tissue

  Human choroid plexus

  Package Size

  0.5 million cells/vial  

  Passage Number

  P2

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Epithelial Cell Growth Medium (Cat# MD-0041)

References

[1] Segal, M. B. (1993). Extracellular and cerebrospinal fluid. Journal of Inherited and Metabolic Disorder 16, 617-638. 
[2] Speake, T., Kajita, H., Smith, C. P. and Brown, P. D. (2002) Inward-rectifying anion channels are expressed in the epithelial cells of choroid plexus isolated from ClC-2 'knock-out' mice. J Physiol 539(Pt 2):385-90. 
[3] Johanson CE, Palm DE, Primiano MJ, McMillan PN, Chan P, Knuckey NW, Stopa EG. (2000) Choroid plexus recovery after transient forebrain ischemia: role of growth factors and other repair mechanisms. Cell Mol Neurobiol 20(2):197-216.

[1] Segal, M. B. (1993). Extracellular and cerebrospinal fluid. Journal of Inherited and Metabolic Disorder 16, 617-638. 
[2] Speake, T., Kajita, H., Smith, C. P. and Brown, P. D. (2002) Inward-rectifying anion channels are expressed in the epithelial cells of choroid plexus isolated from ClC-2 'knock-out' mice. J Physiol 539(Pt 2):385-90. 
[3] Johanson CE, Palm DE, Primiano MJ, McMillan PN, Chan P, Knuckey NW, Stopa EG. (2000) Choroid plexus recovery after transient forebrain ischemia: role of growth factors and other repair mechanisms. Cell Mol Neurobiol 20(2):197-216.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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