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Human Corneal Epithelial Cells (HCEpC)

Human Corneal Epithelial Cells (HCEpC)

Catalog Number: 10HU-098
Availability: Out Of Stock
Price: $599.00

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Product Description

The cornea is a unique tissue due to its transparency and avascularity. The cornea consists of three distinct cell layers: the outer epithelium, the central stroma, and the inner endothelium. The corneal epithelium plays a role in the innate immune response by sensing the presence of pathogens and providing signals to activate the corneal defense system [1]. Corneal epithelial cells also express a high level of aldehyde dehydrogenase to protect them against UV- and 4-hydroxynonenal-induced cellular damage [2]. The renewal of corneal epithelium is regulated by a host of cytokines, including epidermal growth factor, which activates their cognate receptors in the deeper layers of the epithelium [3]. Cultured corneal epithelial cells can be an alternative to animal testing in toxicology studies. They can also be used to understand the highly integrated balance between corneal epithelial proliferation, differentiation, and cell death.

iXCells Biotechnologies provides high quality HCEpC, which are isolated from the epithelium of the human cornea and cryopreserved at P1, with >0.5 million cells in each vial. HCEpC express cytokeratin-18 and -19 and are characterized by their cobble stone morphology in serum-free culture. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 10 population doublings in Epithelial Cell Growth Medium (Cat# MD-0041). under the condition suggested by iXCells Biotechnologies.

Product Details

  Tissue

  Human cornea

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Epithelial Cell Growth Medium (Cat# MD-0041)

References

[1] Zhang, J., Wu, X. Y. and Yu, F. S. (2005) Inflammatory response of corneal epithelial cells to pseudomonas aeruginosa infection. Curr. Eye Res. 30:527-534. 
[2] Pappa, A., Brown, D., Koutalos, Y., Degregori, J., White, C. and Vasiliou, V. (2005) Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J. Biol. Chem. 280:27998-28006. 
[3]. Yang, H., Mergler, S., Sun, X., Wang, Z, Lu, L., Bonanno, J. A., Pleyer, U. and Reinach, P. S. (2005). TRPC4 knockdown suppresses EGF-induced store operated channel activation and growth in human corneal epithelial cells. J Biol Chem.

[1] Zhang, J., Wu, X. Y. and Yu, F. S. (2005) Inflammatory response of corneal epithelial cells to pseudomonas aeruginosa infection. Curr. Eye Res. 30:527-534. 
[2] Pappa, A., Brown, D., Koutalos, Y., Degregori, J., White, C. and Vasiliou, V. (2005) Human aldehyde dehydrogenase 3A1 inhibits proliferation and promotes survival of human corneal epithelial cells. J. Biol. Chem. 280:27998-28006. 
[3]. Yang, H., Mergler, S., Sun, X., Wang, Z, Lu, L., Bonanno, J. A., Pleyer, U. and Reinach, P. S. (2005). TRPC4 knockdown suppresses EGF-induced store operated channel activation and growth in human corneal epithelial cells. J Biol Chem.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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Corneal Epithelial Cell Growth Medium MD-0064