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Human Coronary Artery Endothelial Cells (HCAECs)

Human Coronary Artery Endothelial Cells (HCAECs)

Catalog Number: 10HU-028
Availability: In Stock
Price: $619.00

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Product Description

Human Coronary Artery Endothelial Cells (HCAECs) line the vessel wall of coronary artery. They are extremely important in regulation of coronary blood flow and cardiac function. HCAEC has been used as a valuable in vitro model system to study the cardiovascular diseases such as thrombosis, atherosclerosis, hypertension, coronary artery diseases [1] and diabetes-related cardiovascular diseases [2].

iXCells Biotechnologies offers HCAECs from human coronary artery from single donors. These HCAECs are characterized by CD31 and vWF/Factor VIII staining (Figure 1). HCAECs are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. These cells are guaranteed to maintain at least 10 population doublings in iXCells optimized Endothelial Cell Medium (Cat# MD-0010).

HCAECs

Figure 1.  HCAECs provided by iXCells are positive for CD31 and vWF, as shown by immunostaining (A and B) and flow analysis (A' and B').  More than 97% of cells are positive for both markers by flow analysis (A' and B'). 

Product Details

  Tissue

  Human coronary artery

  Package Size

  0.5 million cells/vial  

  Passage Number

  P2

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Medium Kit (Cat# MD-0010)

References

[1]  Besler C,et al and Landmesser U. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest. 2011; 121 (7): 2693-2708.

[2]  Eriksson L and Nystrom T. Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis. Cardiovasc Diabetol. 2014; 13:152

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[1]  Besler C,et al and Landmesser U. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest. 2011; 121 (7): 2693-2708.

[2]  Eriksson L and Nystrom T. Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis. Cardiovasc Diabetol. 2014; 13:152

 

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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