Welcome visitor you can login or create an account.

Shopping Cart

0 item(s) - $0.00
Your shopping cart is empty!
Human Dermal Lymphatic Endothelial Cells (HDLEC)

Human Dermal Lymphatic Endothelial Cells (HDLEC)

Catalog Number: 10HU-057
Availability: Out Of Stock
Price: $549.00

Available Options

* Package Size (Required):

Qty:     - OR -   Add to Wish List
Add to Compare

Product Description

The lymphatic system is an essential part of the immune system. It serves distinct yet complementary function with the blood vascular system in maintaining tissue homeostasis. The lymphatic system returns fluid and macromolecules from the tissues back into blood circulation and, thus, plays a vital role in the regulation of fluid, protein, and pressure equilibrium in tissues [1]. Although lymphatic capillary endothelial cells have many properties in common with the endothelium of blood vessels, they also have distinct structural characteristics reflecting their specific functions. Lymphatic capillaries lack mural cells and are characterized by an incomplete or absent basement membrane [2]. Lymphatic endothelium typically contains numerous invaginations and cytoplasmic vesicles as well as characteristic overlapping intercellular junctions [3]. One of the most striking characteristics of the lymphatic capillary is its integration within the interstitium which is connected to the extracellular matrix by fine strands of elastic fibers.

iXCells Biotechnologies provides high quality Human Dermal Lymphatic Endothelial Cells (HDLEC), which are isolated from human dermal tissue and cryopreserved at P2, with >0.5 million cells in each vial. HDLEC stain positive for vWF/Factor VIII, CD31 (PECAM), podoplanin, and Lyve1 and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for 12 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies. 

Product Details

  Tissue

  Human dermal tissue

  Package Size

  0.5 million cells/vial  

  Passage Number

  P2

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Swartz, A. and Skobe, M. (2001) Lymphatic function, lymphangiogenesis, and cancer metastasis. Microsc. Res. Tech. 55:92-99. 
[2] Leak, L. V. (1970) Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface. Microvasc. Res. 2, 361-391 
[3] Podgrabinska, S., Braun, P., Velasco, P., Kloos, B., Pepper, M., Jackson, D. and Skobe, M. (2002) Molecular characterization of lymphatic endothelial cells. PNAS 99:16069-16074.

[1] Swartz, A. and Skobe, M. (2001) Lymphatic function, lymphangiogenesis, and cancer metastasis. Microsc. Res. Tech. 55:92-99. 
[2] Leak, L. V. (1970) Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface. Microvasc. Res. 2, 361-391 
[3] Podgrabinska, S., Braun, P., Velasco, P., Kloos, B., Pepper, M., Jackson, D. and Skobe, M. (2002) Molecular characterization of lymphatic endothelial cells. PNAS 99:16069-16074.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

Related Products (1)
Name Description Catalog number
Endothelial Cell Growth Medium MD-0010