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Human Hepatic Sinusoidal Endothelial Cells (HHSEC, Adult)

Human Hepatic Sinusoidal Endothelial Cells (HHSEC, Adult)

Catalog Number: 10HU-021
Availability: In Stock
Price: $649.00

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Product Description

Human liver contains two distinct endothelial cell types: vascular and sinusoidal. Human Hepatic Sinusoidal Endothelial Cells (HHSEC) are microvascular endothelial cells that exhibit a unique phenotype compared to other endothelial cells—they function as dendritic cells to present antigen for CD4+ T cells. Thus, HHSEC are actively involved in the regulation of the immune response in the liver [1]. HHSEC are actively involved in liver repair as dynamic regulators respond rapidly and locally to environmental zonal stimuli [2].

iXCells Biotechnologies provides high quality HHSEC, which are isolated from normal human liver and cryopreserved at P2, with >0.5 million cells in each vial. HHSEC express vWF/Factor VIII and CD31 (Figure 1). They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies. 

Figure 1.  HHSECs provided by iXCells are positive for CD31 (A) and vWF (B), as shown by immunostaining. Flow analysis showed that more than 98% of cells are CD31 positive (A'), and more than 99% are vWF positive (B').

Product Details

  Tissue

  Normal adult human liver 

  Package Size

  0.5 million cells/vial  

  Passage Number

  P2

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

 
 

References

[1]  Limmer A, and Knolle PA. Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell. Arch Immunol Ther Exp (Warsz) 2001; 49 (1): S7-11.

[2]  Wach KE etc. Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver. Hepatoloty 2001; 33 (2): 363-378.

[1]  Limmer A, and Knolle PA. Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell. Arch Immunol Ther Exp (Warsz) 2001; 49 (1): S7-11.

[2]  Wach KE etc. Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liver. Hepatoloty 2001; 33 (2): 363-378.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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