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Human Iris Pigment Epithelial Cells (HIPEpC)

Human Iris Pigment Epithelial Cells (HIPEpC)

Catalog Number: 10HU-099
Availability: Out Of Stock
Price: $649.00

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Product Description

The iris is a pigmented disk with a variable aperture which controls the size of the pupil and the amount of light reaching the retina. It consists of the anterior limiting layer, the stroma, the dilator muscle layer, and the posterior pigmented epithelium. The primary human iris pigment epithelial cells (HIPEpC) share the same embryonic origin as retinal pigment epithelial cells (RPE) and thus exhibit similar functional properties as RPE, including turnover of photoreceptors and synthesis of trophic factors [1]. Previous studies showed that HIPEpC transplanted into the subretinal space inhibited abnormal neovascularization and photoreceptor degeneration, which suggests that HIPEpC transplantation may be used in the future to treat retinal disorders [2]. 

HIPEpC from iXCells Biotechnologies are isolated from human iris. HIPEpC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HIPEpC are characterized by immunofluorescence with antibodies specific to cytokeratin-18, vimentin, and fibronectin. HIPEpC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HIPEpC are guaranteed to further expand for 10 population doublings in Epithelial Cell Growth Medium (Cat# MD-0041).

Product Details

  Tissue

  Human iris

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Epithelial Cell Growth Medium (Cat# MD-0041)

References

[1]. Semkova, I., Kreppel, F., Welsandt, G., Luther, T., Kozlowski, J., Janicki, H., Kochanek, S. and Schraermeyer, U. (2004) Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye. PNAS 99(20):13090-13095. 
[2]. Crafoord, S. (2000) Experimental transplantation of retinal and iris pigment epithelial cells into the subretinal space. Student Journal of Health Sciences. 3(1):22. 
[3]. Sugita, S. and Streilein, J. W. (2004) Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 198:161-171.

[1]. Semkova, I., Kreppel, F., Welsandt, G., Luther, T., Kozlowski, J., Janicki, H., Kochanek, S. and Schraermeyer, U. (2004) Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye. PNAS 99(20):13090-13095. 
[2]. Crafoord, S. (2000) Experimental transplantation of retinal and iris pigment epithelial cells into the subretinal space. Student Journal of Health Sciences. 3(1):22. 
[3]. Sugita, S. and Streilein, J. W. (2004) Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 198:161-171.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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