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Human Lens Epithelial Cells (HLEpC)

Human Lens Epithelial Cells (HLEpC)

Catalog Number: 10HU-100
Availability: Out Of Stock
Price: $679.00

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Product Description

The mammalian lens consists of two cell types, lens fiber cells which form the bulk of the lens, and a monolayer of epithelial cells that cover the anterior surface of the fibers. Lens epithelial cells are responsible for homeostasis regulation of the lens, including electrolyte and fluid transport [1]. Under normal development, lens epithelial cells progressively differentiate and mature. Lens epithelial cells then migrate from the equatorial region into the interior of the lens to produce transparent crystallins, elongate to form lens fiber cells, and eventually lose their nuclei and other organelles [2]. Studies have shown that lens epithelial cell differentiation and lens polarization are regulated by growth factors present in the ocular fluids [3], such as epidermal growth factor, basic fibroblast growth factor, insulin growth factor, and insulin [4].

iXCells Biotechnologies provides high quality Human Lens Epithelial Cells (HLEpC), which are isolated from human lens and cryopreserved at P1, with >0.5 million cells in each vial. HLEpC express cytokeratin-18, -19, and fibronectin. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 10 population doublings in ​ Epithelial Cell Growth Medium (Cat# MD-0041) under the condition suggested by iXCells Biotechnologies.

Product Details

  Tissue

  Human lens

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Epithelial Cell Growth Medium (Cat# MD-0041)

References

[1]. Wagner, L. M. and Takemoto, D. J. (2001) PKCa and PKC overexpression causes lentoid body formation in the N/N 1003A rabbit lens epithelial cell line. Molecular Vision 7: 138-144.
[2]. Lang, R. A. (1999) Which factors stimulate lens fiber cell differentiation in vivo Invest Opthalmol Vis Sci 40:3075-8. 
[3]. Leenders, W. P., van Genesen, S. T., Schoenmakers, J. G., van Zoelen, E. J., Lubsen, N. H. (1997) Synergism between temporally distinct growth factors: bFGF, insulin and lens cell differentiation. Mech Dev. 67:193-201.

[1]. Wagner, L. M. and Takemoto, D. J. (2001) PKCa and PKC overexpression causes lentoid body formation in the N/N 1003A rabbit lens epithelial cell line. Molecular Vision 7: 138-144.
[2]. Lang, R. A. (1999) Which factors stimulate lens fiber cell differentiation in vivo Invest Opthalmol Vis Sci 40:3075-8. 
[3]. Leenders, W. P., van Genesen, S. T., Schoenmakers, J. G., van Zoelen, E. J., Lubsen, N. H. (1997) Synergism between temporally distinct growth factors: bFGF, insulin and lens cell differentiation. Mech Dev. 67:193-201.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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Epithelial Cell Growth Medium MD-0041