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Human Lymphatic Endothelial Cells (HLEC)

Human Lymphatic Endothelial Cells (HLEC)

Catalog Number: 10HU-067
Availability: Out Of Stock
Price: $679.00

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Product Description

The lymphatic system is an essential part of the immune system. It helps maintain tissue homeostasis, including interstitial protein transport, tissue fluid balance, and development of cellular immunity. Lymph nodes, which are located throughout the lymphatic system, contain large numbers of lymphocytes, macrophages and antigen presenting cells that together initiate primary immune response [1]. Specialized lymphatic endothelial cells (HLEC) in the cortex assist in the primary immune response by recruiting intravascular lymphocytes as they circulate past [2]. In addition, HLEC are responsible for facilitating the transmigration of intravascular lymphocytes into the reticular meshwork where the lymphocytes can interact with antigen presenting cells [2]. HLEC have been shown to be associated with chronic inflammation and cancers [3].

HLEC from iXCells Biotechnologies are isolated from human lymph node. HLEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HLEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM), and by uptake of DiI-Ac-LDL. HLEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HLEC are guaranteed to further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010).

Product Details

  Tissue

  Human adipose tissue

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Swartz, A. and Skobe, M. (2001) Lymphatic function, lymphangiogenesis, and cancer metastasis. Microsc. Res. Tech. 55:92-99. 
[2] Leak, L. V. (1970) Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface. Microvasc. Res. 2, 361-391 
[3] Podgrabinska, S., Braun, P., Velasco, P., Kloos, B., Pepper, M., Jackson, D. and Skobe, M. (2002) Molecular characterization of lymphatic endothelial cells. PNAS 99:16069-16074.

[1] Swartz, A. and Skobe, M. (2001) Lymphatic function, lymphangiogenesis, and cancer metastasis. Microsc. Res. Tech. 55:92-99. 
[2] Leak, L. V. (1970) Electron microscopic observations on lymphatic capillaries and the structural components of the connective tissue-lymph interface. Microvasc. Res. 2, 361-391 
[3] Podgrabinska, S., Braun, P., Velasco, P., Kloos, B., Pepper, M., Jackson, D. and Skobe, M. (2002) Molecular characterization of lymphatic endothelial cells. PNAS 99:16069-16074.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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