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Human Mammary Vascular Endothelial Cells (HMVEC)

Human Mammary Vascular Endothelial Cells (HMVEC)

Catalog Number: 10HU-068
Availability: Out Of Stock
Price: $679.00

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Product Description

Vascular endothelial cells lining the blood vessels actively participate in many vital biological processes. Studies have shown that mammary vascular endothelial cells (HMVEC) secrete a mammary-derived growth inhibitor to modulate endothelial cell proliferation and differentiation of the mammary gland [1]. HMVEC also regulate trafficking of lymphocytes and the inflammatory response, and are thus implicated in mastitis [2]. Further studies demonstrate a critical role for HMVEC in breast cancer development through angiogenesis [3-5]. HMVEC cultures are a great model for identifying targets for therapeutic development in breast cancer.

HMVEC from iXCells Biotechnologies are isolated from human breast. HMVEC are cryopreserved after purification and delivered frozen.  Each vial contains >0.5 million cells in 1 ml volume. HMVEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM), and by uptake of DiI-Ac-LDL.  HMVEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi.  HMVEC are guaranteed to further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010).

Product Details

  Tissue

  Human breast

  Package Size

  0.5 million cells/vial  

  Passage Number

  P2

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] KM. Ahem, MR. Davis & IM. Sordillo (1995) Isolation and characterization of bovine mammary endothelial cells. Method in Cell Science. 17(1):41-46. 
[2] AG. Naccarato, P. Viacava, G. Bocci, G. Fanelli, P. Aretini, A. Lonobile, G. Montruccoli and G. Bevilacqua (2003) Definition of the microvascular pattern of the normal human adult mammary gland. J. Anat. 203:599-603. 
[3] V. Sigurdsson, AJR. Fridriksdottir. J. Kjartansson, JG. Jonasson, M. Steinarsdottir, OW. Petersen, HM. Ogmundsdottir, and T Gudjsonsson (2006) Human breast microvascular endothelial cells retain phenotypic traits in long-ter finite life span culture. In Vitro Cellular & Developmental Biology - Animal 42(10):332-340.

[1] KM. Ahem, MR. Davis & IM. Sordillo (1995) Isolation and characterization of bovine mammary endothelial cells. Method in Cell Science. 17(1):41-46. 
[2] AG. Naccarato, P. Viacava, G. Bocci, G. Fanelli, P. Aretini, A. Lonobile, G. Montruccoli and G. Bevilacqua (2003) Definition of the microvascular pattern of the normal human adult mammary gland. J. Anat. 203:599-603. 
[3] V. Sigurdsson, AJR. Fridriksdottir. J. Kjartansson, JG. Jonasson, M. Steinarsdottir, OW. Petersen, HM. Ogmundsdottir, and T Gudjsonsson (2006) Human breast microvascular endothelial cells retain phenotypic traits in long-ter finite life span culture. In Vitro Cellular & Developmental Biology - Animal 42(10):332-340.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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