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Human Myometrial Microvascular Endothelial Cells (HMMEC)

Human Myometrial Microvascular Endothelial Cells (HMMEC)

Catalog Number: 10HU-069
Availability: Out Of Stock
Price: $639.00

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Product Description

Primary human myometrial microvascular endothelial cells (HMMEC) are located in the myometrium between the endometrium and the serosa of the uterus and exhibit typical cobblestone morphology. During pregnancy, angiogenesis occurs through HMMEC proliferation in order to support the hypertrophy of the myometrial smooth muscle cell layer [1]. Significant evidence also indicates that endothelial cell dysfunction in the myometrium may contribute to the development of preeclampsia [2]. In addition, HMMEC proliferation and angiogenesis may play a role in the formation of leiomyomata [2]. Studies have shown that HMMEC express the oxytocin receptor, which may promote vasodilation in the microvasculature of the myometrium [3]. Human HMMEC are a useful in vitro model to elucidate the mechanisms of angiogenesis and to develop treatments for female reproductive tract disorders. 

HMMEC from iXCells Biotechnologies are isolated from human uterus. HMMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HMMEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM), and by uptake of DiI-Ac-LDL. HMMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HMMEC are guaranteed to further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010).

Product Details

  Tissue

  Human uterus

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Gargett C, Bucak K, Rogers P. (2000) Isolation, characterization and long-term culture of human myometrial microvascular endothelial cells. Hum Reprod. 15(2): 293-301. 
[2] Hayman R, Brockelsby J, Kenny L, Baker P. (1999) Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. J So Gynecol Investig. 6(1): 3-10. 
[3] Weston G, Cann L, Rogers P. (2003) Myometrial microvascular endothelial cells express oxytocin receptor. BJOG. 110(2):149-156.

[1] Gargett C, Bucak K, Rogers P. (2000) Isolation, characterization and long-term culture of human myometrial microvascular endothelial cells. Hum Reprod. 15(2): 293-301. 
[2] Hayman R, Brockelsby J, Kenny L, Baker P. (1999) Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. J So Gynecol Investig. 6(1): 3-10. 
[3] Weston G, Cann L, Rogers P. (2003) Myometrial microvascular endothelial cells express oxytocin receptor. BJOG. 110(2):149-156.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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