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Human Non-Pigmented Ciliary Epithelial Cells (HNPCEpC)

Human Non-Pigmented Ciliary Epithelial Cells (HNPCEpC)

Catalog Number: 10HU-106
Availability: Out Of Stock
Price: $629.00

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Product Description

The ciliary epithelium rests upon the leaf-like projections of the ciliary processes in the posterior chamber, overlaying the core of stroma and blood vessels. It consists of two layers of columnar cells, which appear structurally and functionally distinct. The outer layer of epithelium is pigmented, but the inner layer, which resides next to the aqueous, is not. In mammalian eyes, the non-pigmented ciliary epithelial cells (NPCEpC) are largely responsible for the aqueous humor inflow. NPCEpC generate an osmotic gradient through solute transfer, which then results in water movement from the stroma into the posterior chamber [1]. Other studies have implicated NPCEpC in the synthesis of macro-molecules required for photo-transduction [2] and the development of rare adenomas in the ciliary body [3]. 

HNPCEpC from iXCells Biotechnologies are isolated from human ciliary body. HNPCEpC are cryopreserved at P1 and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HNPCEpC are characterized by immunofluorescence with antibodies specific to cytokeratin-18 and -19. HNPCEpC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HNPCEpC are guaranteed to further expand for 12 population doublings in Epithelial Cell Growth Medium (Cat# MD-0041).

Product Details

  Tissue

  Human ciliary body

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Epithelial Cell Growth Medium (Cat# MD-0041)

References

[1]. Krupin, T. and Civan, M. M. (1995) in The Glaucomas, eds. Ritch, R., Shields, M. B. & Krupin, T. (Mosby, St. Louis), pp. 251-280. 
[2]. Raviola, G. and Raviola, E. (1978) Intercellular junctions in the ciliary epithelium. Investigative Ophthalmology & Visual Science 17:958-981.

[1]. Krupin, T. and Civan, M. M. (1995) in The Glaucomas, eds. Ritch, R., Shields, M. B. & Krupin, T. (Mosby, St. Louis), pp. 251-280. 
[2]. Raviola, G. and Raviola, E. (1978) Intercellular junctions in the ciliary epithelium. Investigative Ophthalmology & Visual Science 17:958-981.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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