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Human Peripheral Blood CD19+ B Cells

Human Peripheral Blood CD19+ B Cells

Catalog Number: 10HU-026
Availability: In Stock
Price: $499.00

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Product Description

B cells, also known as B lymphocytes, are a subtype of lymphocyte in white blood cells [1]. They play a critical role in the humoral immunity component of the adaptive immune system by secreting antibodies[1]. They also function in immune system as antigen presentation cells and by secretion of cytokines[1].

CD19 (Cluster of Differentiation 19) is an important surface marker for B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 [2] and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase.

iXCells Biotechnologies offers CD19+ B Cells isolated from normal human peripheral blood mononuclear cells (PBMCs) using positive immunomagnetic selection. > 95% of the cells are CD19+ as showed by flow cytometric analysis (Figure 1). 

CD19+ B Cells

Figure 1. Flow cytometric analysis showed that >95% cells are CD19 positive. 

Product Details

  Tissue

  Normal human peripheral blood

  Package Size

  5 x106 cells/vial

  Passage Number

  P0

  Purity

  > 95%

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Suspension

  Media

  Blood Cell Culture Medium (Cat# MDBCC)

References

[1]  Murphy, Kenneth. 2012. Janeway’s Immunobiology 8th Edition. New York, NY: Garland Science.

[2]  Bradbury LE, Kansas GS, Levy S, Evans RL, and Tedder TF. “The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules”. Journal of Immunology 1992; 149 (9):2841-2850.

 Download Datasheet

[1]  Murphy, Kenneth. 2012. Janeway’s Immunobiology 8th Edition. New York, NY: Garland Science.

[2]  Bradbury LE, Kansas GS, Levy S, Evans RL, and Tedder TF. “The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules”. Journal of Immunology 1992; 149 (9):2841-2850.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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