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Human Peripheral Blood CD8+ Cytotoxic T Cells

Human Peripheral Blood CD8+ Cytotoxic T Cells

Catalog Number: 10HU-024
Availability: In Stock
Price: $399.00

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Product Description

The CD8+ T cells, also known as Cytotoxic T cells (TC cells), are a type of T cells that kill cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways. Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen, and a glycoprotein called CD8 which binds to the constant portion of the class I MHC molecule. When exposed to infected/dysfunctional somatic cells, CD8+ T cells release the cytotoxins perforin, granzymes, and granulysin, which triggers the caspase cascade and eventually leads to apoptosis.  CD8+ T cells have been implicated in the pathogenesis of hepatitis B virus infection [1], arthritis [2] etc.

iXCells Biotechnologies offers CD8+ T cells isolated from normal human peripheral blood mononuclear cells (PBMCs) using positive immunomagnetic selection.  > 93% of the cells are CD8+ as showed by flow cytometric analysis (Figure 1). 

CD8+ T Cells

Figure 1. Flow cytometric analysis showed that >93% of the cells are CD8+. 

Product Details

  Tissue

  Normal human peripheral blood

  Package Size

  5.0x106 cells/vial, 1.0x107 cells/vial

  Purity

  >93%

  Passage Number

  P0

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Suspension

  Media

  Blood Cell Culture Medium (Cat# MD-0007)

 

References

[1]  Iannacone, Matteo; Sitia, Giovanni; Guidotti, Luca G (2006). "Pathogenetic and antiviral immune responses against hepatitis B virus". Future Virology 1 (2): 189–96.

[2]   Subramanian S and Ramalingam K (2005). "Electron microscopic evidence on the participation Cytotoxic T Lymphocytes and Macrophages in Mtb adjuvant induced connective tissue inflammation and arthritogenesis in Rattus norvegicus". Asian Journal of Microbiology, Biotechnology and Environmental Sciences 7 (2): 227–233.

 Download Datasheet

[1]  Iannacone, Matteo; Sitia, Giovanni; Guidotti, Luca G (2006). "Pathogenetic and antiviral immune responses against hepatitis B virus". Future Virology 1 (2): 189–96.

[2]   Subramanian S and Ramalingam K (2005). "Electron microscopic evidence on the participation Cytotoxic T Lymphocytes and Macrophages in Mtb adjuvant induced connective tissue inflammation and arthritogenesis in Rattus norvegicus". Asian Journal of Microbiology, Biotechnology and Environmental Sciences 7 (2): 227–233.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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Blood Cell Culture Medium MD-0007