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Human Placental Vascular Endothelial Cells (HPVEC)

Human Placental Vascular Endothelial Cells (HPVEC)

Catalog Number: 10HU-072
Availability: Out Of Stock
Price: $639.00

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Product Description

The human placenta is a well vascularized organ that plays an essential role in fetal development by providing nutrients to the fetus, producing pregnancy hormones, excreting waste, and protecting the fetus from harmful substances [1, 2]. The placenta is comprised of an extensive vascular network that when fully developed covers a surface area of 15m2 [2]. During pregnancy, the placental vasculature undergoes widespread remodeling, in part due to endothelial cell proliferation and elongation [2]. Vascular defects due to endothelial cell dysfunction in the placenta can contribute to the development of disorders such as placental insufficiency, intrauterine growth restriction, and pre-eclampsia [1, 2, 3].  Human Placental Vascular Endothelial Cells (HPVEC) are an excellent in vitro model to study vascular defects in the placenta and elucidate the mechanisms of angiogenesis and vasculogenesis.

iXCells Biotechnologies provides high quality HPVEC, which are isolated from normal  human placenta tissue and cryopreserved at P1, with >0.5 million cells in each vial. HPVEC express vWF/Factor VIII and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HPVEC can further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies. 

Product Details

  Tissue

  Human placenta

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Regnault T, Galan H, Parker T, Anthony R. (2002) "Placental development in normal and compromised pregnancies - a review." Placenta. 23:S119-S129. 
[2] Burton G, Charnock-Jones D, Jauniaux E. (2009) "Regulation of vascular growth and function in the human placenta." Reproduction. 138: 895-902.
[3] Szpera-Gozdziewicz A, Breborowicz G. (2014) "Endothelial dysfunction in the pathogenesis of pre-eclampsia." Front Biosci (Landmark Ed). 19:734-746.

[1] Regnault T, Galan H, Parker T, Anthony R. (2002) "Placental development in normal and compromised pregnancies - a review." Placenta. 23:S119-S129. 
[2] Burton G, Charnock-Jones D, Jauniaux E. (2009) "Regulation of vascular growth and function in the human placenta." Reproduction. 138: 895-902.
[3] Szpera-Gozdziewicz A, Breborowicz G. (2014) "Endothelial dysfunction in the pathogenesis of pre-eclampsia." Front Biosci (Landmark Ed). 19:734-746.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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