Human Adipose Derived Stem Cells (ADSCs, Type 1 Diabetes)
Human Adipose Derived Stem Cells (ADSCs) are isolated from human lipoaspirate tissue collected during elective surgical liposuctiom procedures. It has been shown that the ADSCs demonstrate very similar phenotypic and functional characteristics to that of bone marrow-derived mesenchymal stem cells. Thousands of articles have been published on ADSCs using a variety of terminology, including adipose-derived mesenchymal stem cells (AD-MSCs), adipose MSCs (AMSCs), adipose-derived adult stem (ADAS) cells, and adipose stromal/stem cells (ASCs). Normal Human ADSCs have been reported to differentiate down many different lineages including chondrogenic, osteogenic, adipogenic and neural.
iXCells human T1D ADSCs are isolated from the lipoaspirate tissue of the fully diagnosed Type 1 Diabetes donors. These cells are expanded for one passage in Preadipocyte Growth Medium (Cat# MDPGM) and then cryopreserved at primary passage. iXCells ADSCs are positive for CD29, CD44, CD73, CD90, CD105, and negative for CD14, CD31, and CD45 (Figure 1). Pertinent additional donor information, including Body Mass Index (BMI) may be available upon request. All the cells provided by iXCells are negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C. A Certificate of Analysis is provided for each cell lot purchased.
Normal human ADSCs are available as a separate product (Cat# 10HU-001). Diseased state ADSCs from donors with Type 2 Diabetes (T2D), Alzheimers's Disease (AD), Parkinson's Disease (PD), Amyotrophic Lateral Sclerosis (ALS) are also available.
Figure 1. Immunostaining of cell surface markers of human ADSCs.