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Human Adrenal Fibroblasts (HAdF)

Human Adrenal Fibroblasts (HAdF)

Catalog Number: 10HU-119
Availability: Out Of Stock
Price: $599.00

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Product Description

The adrenal gland plays an essential role in regulating homeostasis in the body through the secretion of corticosteroid and androgen hormones. Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies. This is mainly because they are one of easiest types of cells to grow in culture, and their durability makes them amenable to a wide variety of manipulations ranging from studies employing gene transfection to microinjection [1]. Fibroblasts secrete a non-rigid extracellular matrix that is rich in type I and/or type III collagen [2]. They are responsible for much of the synthesis of extracellular matrix in connective tissues and play major roles in wound healing. Many diseases are associated with fibroblasts, either because fibroblasts are implicated in their etiology or because of the fibrosis that accompanies damage to other cell types in tissues. For example, the development of bowl stenosis in Crohn’s disease patients is caused by extreme fibroblast proliferation and extracellular matrix expansion [3].

HAdF from iXCells Biotechnologies are isolated from human adrenal tissue. HAdF are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. HAdF are characterized by their spindle morphology and immunofluorescence with antibody specific to fibronectin. HAdF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAdF are guaranteed to further expand for 12 population doublings in Fibroblast Growth Medium (Cat# MD-0011)

Product Details

  Tissue

  Human adrenal tissue

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Fibroblast Growth Medium (Cat# MD-0011)

References

[1] Conrad GW, Hart GW, Chen Y. (1977) Differences in vitro between fibroblast-like cells from cornea, heart, and skin of embryonic chicks. J. Cell Sci. 26: 119-37.
[2] Gabbiani G, Rungger-Brandle E. (1981) The fibroblast. In Glynn LE, Handbook of Inflammation, Vol. 3: In Tissue Repair and Regeneration (pp. 1-50) Amsterdam: Elsevier.
[3] Luna J, Masamunt, MC, Rickmann M, Mora R, Espana C, Delgado S, Llach, J, Vaquero E, Sans M. (2011) Rocotrienols have potent antifibrogenic effects in human intestinal fibroblasts. Inflamm Bowel Dis. 17: 732-41.

[1] Conrad GW, Hart GW, Chen Y. (1977) Differences in vitro between fibroblast-like cells from cornea, heart, and skin of embryonic chicks. J. Cell Sci. 26: 119-37.
[2] Gabbiani G, Rungger-Brandle E. (1981) The fibroblast. In Glynn LE, Handbook of Inflammation, Vol. 3: In Tissue Repair and Regeneration (pp. 1-50) Amsterdam: Elsevier.
[3] Luna J, Masamunt, MC, Rickmann M, Mora R, Espana C, Delgado S, Llach, J, Vaquero E, Sans M. (2011) Rocotrienols have potent antifibrogenic effects in human intestinal fibroblasts. Inflamm Bowel Dis. 17: 732-41.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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