Human Chondrocytes – Osteoarthritis (HC-oa)

Description

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Product Description

HC-oa Human Chondrocytes are derived from human articular cartilage of donors with osteoarthritis. Osteoarthritis is an inflammatory disease characterized by increased degradation of cartilage tissue in the joint due to overproduction of enzymes degrading the extracellular matrix. Despite the initial proliferation and activation of chondrocytes, they are not able to efficiently repair the degrading cartilage. Instead, chondrocytes undergo terminal differentiation and eventually apoptose, leading to mineralization of cartilage in a process resembling bone formation during development. Thus, HC-o provide a useful model to study changes in chondrocyte biology in response to abnormal environment of the osteoarthritis joint.

iXCells Biotechnologies provides high quality Human Chondrocytes-Osteoarthritis (HC-oa), which are isolated from human articular cartilage of donors with osteoarthritis and cryopreserved at P1, with >0.5 million cells in each vial. These HC-oa are positive for aggrecan after differentiation and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HC-oa can further expand for 10 population doublings in Chondrocyte Medium (Cat# MD-0040) under the condition suggested by iXCells Biotechnologies.

Product Details

References

[1] Xue, J., J. Wang, Q. Liu, and A. Luo. 2013. Tumor necrosis factor-α induces ADAMTS-4 expression in human osteoarthritis chondrocytes. Molecular medicine reports: 10.3892/mmr.2013.1729.2005

[2] Quintavalla, J., C. Kumar, S. Daouti, E. Slosberg, and S. Uziel-Fusi. 2005. Chondrocyte cluster formation in agarose cultures as a functional assay to identify genes expressed in osteoarthritis. Journal of cellular physiology. 204:560-566.