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Human Pericardial Fibroblasts (HPcF)

Human Pericardial Fibroblasts (HPcF)

Catalog Number: 10HU-141
Availability: Out Of Stock
Price: $599.00

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Product Description

Human Pericardial Fibroblasts (HPcF) are the major cell type of the pericardium. They produce collagens and help form the thin but strong pericardium to serve as a protective sac for the heart by providing structural support and lubrication, and preventing excessive dilation of the heart [1, 2]. Dysregulated activation and proliferation of HPcF, collagen and fibrin deposition, chronic inflammation, and scarring have been implicated in constrictive pericarditis, where pericardium hardening eventually prevents the heart from expanding [3, 4]. Associations between fibroblast activation and immunomodulation make HPcF cultures a useful tool for studying progressive sclerosing pericarditis.

iXCells Biotechnologies provides high quality HPcF, which are isolated from human heart and cryopreserved at P0, with >0.5 million cells in each vial. HPcF express fibronectin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for 16 population doublings in Fibroblast Growth Medium (Cat# MD-0011) under the condition suggested by iXCells Biotechnologies. 

Product Details

  Tissue

  Human heart

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Fibroblast Growth Medium (Cat# MD-0011)

References

[1] Gabbiani, G., Rungger-Brandle, E., The fibroblast. In Tissue Repair and Regeneration (L. E. Glynn, ed.), pp 1- 50. Handbook of Inflammation, Vol. 3. Amsterdam, Elsevier, 1981.
[2] Conrad, G. W., Hart, G. W., Chen, Y. (1977) Differences in vitro between fibroblast-like cells from cornea, heart, and skin of embryonic chicks. J. Cell Sci. 26:119-137.

[1] Gabbiani, G., Rungger-Brandle, E., The fibroblast. In Tissue Repair and Regeneration (L. E. Glynn, ed.), pp 1- 50. Handbook of Inflammation, Vol. 3. Amsterdam, Elsevier, 1981.
[2] Conrad, G. W., Hart, G. W., Chen, Y. (1977) Differences in vitro between fibroblast-like cells from cornea, heart, and skin of embryonic chicks. J. Cell Sci. 26:119-137.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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Fibroblast Growth Medium MD-0011