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Human Periodontal Ligament Fibroblasts (HPLF)

Human Periodontal Ligament Fibroblasts (HPLF)

Catalog Number: 10HU-142
Availability: Out Of Stock
Price: $589.00

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Product Description

The periodontal ligament is connective tissue located between the cementum of the teeth and the alveolar bone of the mandibula. It plays an integral role in the maintenance and regeneration of periodontal tissue. The cells responsible for maintaining this tissue are thought to be fibroblasts, which can be either multipotent or composed of heterogeneous cell populations that differ in their function. Despite the similar morphology with gingival fibroblasts, periodontal ligament fibroblasts (PLF) appear to display distinct functional activities in the maintenance of tissue integrity [1]. It is known that human PLF (HPLF) produce osteoblast-related extracellular matrix proteins and show higher alkaline phosphatase activity compared with gingival fibroblasts [2]. HPLF actively participate in immune and inflammatory events in periodontal diseases [3].

iXCells Biotechnologies provides high quality HPLF, which are isolated from human periodontal tissue and cryopreserved at P1, with >0.5 million cells in each vial. HPLF express fibronectin and are characterized by their spindle-shaped morphology. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 16 population doublings in Fibroblast Growth Medium (Cat# MD-0011) under the condition suggested by iXCells Biotechnologies. 

Product Details

  Tissue

  Human periodontal tissue

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Fibroblast Growth Medium (Cat# MD-0011)

References

[1] Han, X., Amar, S. (2002) Identification of genes differentially expressed in cultured human periodontal ligament fibroblasts vs. human gingival fibroblasts by DNA microarray analysis. J Dent Res. 81(6):399-405. 
[2] Murakami, Y., Kojima, T., Nagasawa, T., Kobayashi, H., Ishikawa, I. (2003) Novel isolation of alkaline phosphatase-positive subpopulation from periodontal ligament fibroblasts. J Periodontol. 74(6):780-6. 
[3] Takashiba, S., Naruishi, K., Murayama, Y. (2003) Perspective of cytokine regulation for periodontal treatment: fibroblast biology. J Periodontol. 74(1):103-10.

[1] Han, X., Amar, S. (2002) Identification of genes differentially expressed in cultured human periodontal ligament fibroblasts vs. human gingival fibroblasts by DNA microarray analysis. J Dent Res. 81(6):399-405. 
[2] Murakami, Y., Kojima, T., Nagasawa, T., Kobayashi, H., Ishikawa, I. (2003) Novel isolation of alkaline phosphatase-positive subpopulation from periodontal ligament fibroblasts. J Periodontol. 74(6):780-6. 
[3] Takashiba, S., Naruishi, K., Murayama, Y. (2003) Perspective of cytokine regulation for periodontal treatment: fibroblast biology. J Periodontol. 74(1):103-10.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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