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Human Renal Glomerular Endothelial Cells (HRGEC)

Human Renal Glomerular Endothelial Cells (HRGEC)

Catalog Number: 10HU-078
Availability: In Stock
Price: $699.00

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Product Description

Human primary renal glomerular endothelial cells (HRGEC) are a specialized microvascular cell type involved in the regulation of glomerular ultrafiltration. They form the inner part of the filtration barrier and are involved in pathophysiological processes in the glomerulum [1]. HRGEC constitutively produce bio-active molecules, which can be amplified by inflammatory and thrombotic molecules [2]. Endothelial cell injury due to a severe glomerular lesion can inhibit angiogenesis and result in sclerosis at the injured site [3,4]. HRGEC injury affects mesangial and epithelial cells and leads to the progression of renal disease [4]. The biological properties of HRGEC remain largely unknown because of difficulties associated with the culturing, cloning and propagation of these cells.

iXCells Biotechnologies provides high quality HRGEC, which are isolated from human kidneys and cryopreserved at P0 after purification, with >0.5 million cells in each vial. HRGEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM), and by the formation of microtubular structures in vitro. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HRGEC can proliferate in Endothelial Cell Growth Medium (Cat# MD-0010), but they are not recommended for further expansion, because the purity of the endothelial population may decrease. 

Product Details

  Tissue

  Human kidneys

  Package Size

  0.5 million cells/vial  

  Passage Number

  P0

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Nangaku, M., Shankland, S. J., Couser, W. G. and Johnson, R. J. (1998) A new model of renal microvascular injury. Curr Opin Nephrol Hypertens 7(4):457-62. 
[2] Kester, M., Nowinski, R. J., Holthofer, H., Marsden, P. A. and Dunn, M. J. (1994) Characterization of platelet-activating factor synthesis in glomerular endothelial cell lines. Kidney Int 46(5):1404-12.
[3] Lee, L. K., Meyer, T. W., Pollock, A. S. and Lovett, D. H. (1995) Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest 96(2):953-64.
[4] Yamanaka, N. and Shimizu, A. (1999) Role of glomerular endothelial damage in progressive renal disease. Kidney Blood Press Res 22(1-2):13-20.

 Download Datasheet

[1] Nangaku, M., Shankland, S. J., Couser, W. G. and Johnson, R. J. (1998) A new model of renal microvascular injury. Curr Opin Nephrol Hypertens 7(4):457-62. 
[2] Kester, M., Nowinski, R. J., Holthofer, H., Marsden, P. A. and Dunn, M. J. (1994) Characterization of platelet-activating factor synthesis in glomerular endothelial cell lines. Kidney Int 46(5):1404-12.
[3] Lee, L. K., Meyer, T. W., Pollock, A. S. and Lovett, D. H. (1995) Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest 96(2):953-64.
[4] Yamanaka, N. and Shimizu, A. (1999) Role of glomerular endothelial damage in progressive renal disease. Kidney Blood Press Res 22(1-2):13-20.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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Endothelial Cell Growth Medium MD-0010