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Human Testicular Endothelial Cells (HTEC)

Human Testicular Endothelial Cells (HTEC)

Catalog Number: 10HU-086
Availability: Out Of Stock
Price: $679.00

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Product Description

Primary Human Testicular Endothelial Cells (HTEC), located in the mesonephros, migrate in the developing embryo from the mesonephros to form the testis vasculature during the process of testis cord formation [1]. The migrating endothelial cells are also essential because they initiate cord formation by creating partitions for the Sertoli and Germ cells [1, 2]. Recent studies have shown that disrupting testis vascular development blocks testis cord formation and thereby prevents proper structural development of the testis [1, 2]. In addition, studies suggest that testicular endothelial cells have similar properties to brain endothelial cells and contribute to the establishment of the blood-testis barrier (BTB) [3]. Cultured HTEC are a useful in vitro model to understand vascular defects in testis dysgenesis and may provide new insight for treatment of male reproductive disorders.

iXCells Biotechnologies provides high quality HTEC, which are isolated from human testis and cryopreserved at P1, with >0.5 million cells in each vial. HTEC express vWF/Factor VIII, CD31 (PECAM), and Dil-Ac-LDL by uptake. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies. 

Product Details

  Tissue

  Human testis

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Combes A, Wilhelm D, Davidson T, Dejana E, Harley V, Sinclair A, Koopman P. (2009) "Endothelial cell migration directs testis cord formation." Dev Biol. 326(1): 112-120. 
[2] Coveney D, Cool J, Oliver T, Capel B. (2008) "Four-dimensional analysis of vascularization during primary development of an organ, the gonad." Proc Natl Acad Sci. 105(20): 7212-7217. 
[3] Holash J, Harik S, Perry G, Stewart P. (1993) "Barrier properties of testis microvessels." Proc Natl Acad Sci. 90: 11069-11073.

[1] Combes A, Wilhelm D, Davidson T, Dejana E, Harley V, Sinclair A, Koopman P. (2009) "Endothelial cell migration directs testis cord formation." Dev Biol. 326(1): 112-120. 
[2] Coveney D, Cool J, Oliver T, Capel B. (2008) "Four-dimensional analysis of vascularization during primary development of an organ, the gonad." Proc Natl Acad Sci. 105(20): 7212-7217. 
[3] Holash J, Harik S, Perry G, Stewart P. (1993) "Barrier properties of testis microvessels." Proc Natl Acad Sci. 90: 11069-11073.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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Endothelial Cell Growth Medium MD-0010