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Human Tonsil Endothelial Cells (HTMEC)

Human Tonsil Endothelial Cells (HTMEC)

Catalog Number: 10HU-224
Availability: Out Of Stock
Price: $629.00

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Product Description

The tonsils are part of the lymphatic system and are located in the pharynx. The tonsils are the immune system’s first defense against foreign pathogens and help to prevent respiratory and gastrointestinal infections. Tonsil endothelial cells (TEC) line the blood vessels and actively participate in fluid balance, cellular transport, and immunity [1]. TEC also perform specialized functions for the tonsils including recruiting lymphocytes from the blood [2, 3]. Studies have shown that TEC express proteins that aid in lymphocyte adhesion and extravasation [3]. Morphological and physiological changes in human TEC (HTEC) can lead to the development of tonsillitis. HTEC are a useful model for studying inflammation in the tonsils.

HTEC from iXCells Biotechnologies are isolated from human tonsil. HTEC are cryopreserved at passage one and delivered frozen.  Each vial contains >5 x 10^5 cells in 1 ml volume. HTEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and CD31 (PECAM). HTEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HTEC are guaranteed to further expand for 10 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010).

Product Details

  Tissue

  Human tonsil 

  Package Size

  0.5 million cells/vial

  Passage Number

  P1

  Shipped

  Proliferating culture

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

References

[1] Kelley P, Tempero R. (2010) "Lymphatic vessel hypertrophy in in inflamed human tonsils." Lymphat Res Biol. 8(2): 121-126. 
[2] Garrafa E, Alessandri G, Benetti A, Turetta D, Corradi A, Cantoni A, Cervi E, Bonardelli S, Parati E, Giulini S, Ensoli B, Caruso A. (2006) "Isolation and characterization of lymphatic microvascular endothelial cells from human tonsils". J Cell Physiol. 207(1): 107-113. 
[3] Palmeri D, Zuo F, Rosen S, Hemmerich S. (2004) "Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking." J Leukoc Biol. 75(5): 910-927. 

[1] Kelley P, Tempero R. (2010) "Lymphatic vessel hypertrophy in in inflamed human tonsils." Lymphat Res Biol. 8(2): 121-126. 
[2] Garrafa E, Alessandri G, Benetti A, Turetta D, Corradi A, Cantoni A, Cervi E, Bonardelli S, Parati E, Giulini S, Ensoli B, Caruso A. (2006) "Isolation and characterization of lymphatic microvascular endothelial cells from human tonsils". J Cell Physiol. 207(1): 107-113. 
[3] Palmeri D, Zuo F, Rosen S, Hemmerich S. (2004) "Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking." J Leukoc Biol. 75(5): 910-927. 

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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