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Bovine Brain Microvascular Endothelial Cells (BBMVEC)

Bovine Brain Microvascular Endothelial Cells (BBMVEC)

Catalog Number: 10BO-005
Availability: Out Of Stock
Price: $559.00

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Product Description

Brain microvascular endothelial cells (BMEC), the major component of the blood-brain barrier, limit the passage of substances, both soluble and cellular, from the blood into the brain. BMEC utilize unique features to distinguish themselves from peripheral endothelial cells, such as 1) intercellular tight junctions that display high electrical resistance and slow paracellular transport, 2) the absence of fenestrae and a reduced level of pinocytic activity, and 3) the expression of specialized pumps that can transport compounds out of the brain via the blood-brain barrier [1-3]. Similar to peripheral endothelial cells, BMEC express, or can be induced to express, cell adhesion molecules on their surface that regulate the extravasation of leukocytes into the brain. Cultured bovine BMEC have been used for studying the molecular and cellular properties of blood-brain barrier because of their unique functions [4]. Understanding the molecular mechanisms of blood-brain barrier regulation may help to optimize drug delivery to the CNS and elucidate new therapies for CNS diseases. 

Bovine Brain Microvascular Endothelial Cells (BBMVEC) from iXCells Biotechnologies are isolated from bovine brain. BBMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. BBMEC are characterized by immunofluorescence with antibody specific to vWF/Factor VIII. BBMEC are negative for mycoplasma, bacteria, yeast, and fungi. BBMEC are guaranteed to further expand for 5 population doublings in Endothelial Cell Growth Medium (Cat# MD-0010).

Product Details

  Tissue

  Bovine brain

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Endothelial Cell Growth Medium (Cat# MD-0010)

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we make no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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Endothelial Cell Growth Medium MD-0010