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Human Pulmonary Artery Smooth Muscle Cells (HPASMC)

Human Pulmonary Artery Smooth Muscle Cells (HPASMC)

Catalog Number: 10HU-203
Availability: Out Of Stock
Price: $599.00

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Product Description

Smooth muscle cells (SMC) are primary contributors to the development of arterial disease [1]. The ability of vascular SMC to switch to a proliferative phenotype is one of the main factors in the development and progression of vascular disease. Pulmonary artery smooth muscle cells (PASMC) express VEGF and FGF-2 and are subjected to mechanical forces during pulsatile blood flow [2]. Chronic lung hypoxia causes vascular remodeling with PASMC hyperplasia, and results in pulmonary hypertension [3]. Cultured PASMC play an important role in vascular disease research and can be used to identify new therapeutic targets to treat pulmonary vascular disease.

iXCells Biotechnologies provides high quality Human Pulmonary Artery Smooth Muscle Cells (HPASMC), which are isolated from human pulmonary arteries and cryopreserved at P1, with >0.5 million cells in each vial. HPASMC express α-smooth muscle actin and desmin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fung. HPASMC can further expand for 12 population doublings in  Smooth Muscle Cell Growth Medium (Cat # MD-0034) under the condition suggested by iXCells Biotechnologies.

Product Details

  Tissue

  Human pulmonary arteries

  Package Size

  0.5 million cells/vial  

  Passage Number

  P1

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Smooth Muscle Cell Growth Medium (Cat # MD-0034)

References

[1] Schwartz, S. M., Campbell, G. R., Campbell, J. H. (1986) Replication of smooth muscle cells in vascular disease. Circ. Res. 58:427-444. 
[2] Fan, Q. I., Vanderpool, K., Marsh, J. D. (2002) A 27 bp cis-acting sequence is essential for L-type calcium channel alpha(1C) subunit expression in vascular smooth muscle cells. Biochim Biophys Acta. 1577:401-11. 
[3] Braun, M., Pietsch, P., Schror, K., Baumann, G., Felix, S. B. (1999) Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc. Res. 41:395-401. 
[4] Quinn, T. P., Schlueter, M., Soifer, S. J., Gutierrez, J. A. (2002) Cyclic mechanical stretch induces VEGF and FGF-2 Expression in pulmonary vascular smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 282:L897-903. 
[5] Rose, F., et al. (2002) Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors. FASEB J. 12:1660-1.

[1] Schwartz, S. M., Campbell, G. R., Campbell, J. H. (1986) Replication of smooth muscle cells in vascular disease. Circ. Res. 58:427-444. 
[2] Fan, Q. I., Vanderpool, K., Marsh, J. D. (2002) A 27 bp cis-acting sequence is essential for L-type calcium channel alpha(1C) subunit expression in vascular smooth muscle cells. Biochim Biophys Acta. 1577:401-11. 
[3] Braun, M., Pietsch, P., Schror, K., Baumann, G., Felix, S. B. (1999) Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc. Res. 41:395-401. 
[4] Quinn, T. P., Schlueter, M., Soifer, S. J., Gutierrez, J. A. (2002) Cyclic mechanical stretch induces VEGF and FGF-2 Expression in pulmonary vascular smooth muscle cells. Am. J. Physiol. Lung Cell Mol. Physiol. 282:L897-903. 
[5] Rose, F., et al. (2002) Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells: role of hypoxia-inducible transcription factors. FASEB J. 12:1660-1.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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