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Rat Hepatic Stellate Cells (RHSC)

Rat Hepatic Stellate Cells (RHSC)

Catalog Number: 10RA-017
Availability: In Stock
Price: $499.00

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Product Description

Hepatic stellate cells (HSC) are pericytes found in the perisinusoidal space presenting myofibroblast-like or lipocyte phenotypes. They participate in the homeostasis, repair, and regeneration of liver extracellular matrix, and control retinol metabolism, storage, and release. Following liver injury, HSC proliferate, transform into myofibroblast-like cells, and produce type I collagen in the fibrotic liver. HSC have been implicated as a regulator of hepatic microcirculation via cell contraction in the pathogenesis of intrahepatic portal hypertension [1]. HSC also possess voltage-activated calcium current, express the low affinity nerve growth factor receptor p75, and undergo apoptosis in response to nerve growth factor stimulation [2, 3]. These insights into the molecular regulation of HSC activation will help lead to new therapeutic approaches in treatment of hepatic fibrosis by reducing morbidity and mortality in patients with chronic liver injury.

iXCells Biotechnologies provides high quality Rat Hepatic Stellate Cells (RHSC), which are isolated from young DS rat liver and cryopreserved at P2, with >0.5 million cells in each vial. RHSC express desmin and α-actin. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 5 population doublings in Stellate Cell Growth Medium (Cat# MD-0014) under the condition suggested by iXCells Biotechnologies.

Product Details

  Tissue

  Young DS rat liver

  Package Size

  0.5 million cells/vial  

  Passage Number

  P2

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Stellate Cell Growth Medium (Cat# MD-0014)

References

[1] Reynaert H, Thompson MG, Thomas T, Geerts A. (2002) Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension. Gut 50:571-581. 
[2] Rockey D. C. (2001) Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin Liver Dis 21(3):337-49.
[3] Oide H, Tateyama M, Wang XE, Hirose M, Itatsu T, Watanabe S, Ochi R, Sato N. (1999) Activated stellate (Ito) cells possess voltage-activated calcium current. Biochim. Biophys. Acta. 1418:158-164. 
[4] Trim N, Morgan S, Evans M, Issa R, Fine D, Afford S, Wilkins B, Iredale J. (2000) Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. Am. J. Pathol. 156(4):1235-1243.

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[1] Reynaert H, Thompson MG, Thomas T, Geerts A. (2002) Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension. Gut 50:571-581. 
[2] Rockey D. C. (2001) Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin Liver Dis 21(3):337-49.
[3] Oide H, Tateyama M, Wang XE, Hirose M, Itatsu T, Watanabe S, Ochi R, Sato N. (1999) Activated stellate (Ito) cells possess voltage-activated calcium current. Biochim. Biophys. Acta. 1418:158-164. 
[4] Trim N, Morgan S, Evans M, Issa R, Fine D, Afford S, Wilkins B, Iredale J. (2000) Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation. Am. J. Pathol. 156(4):1235-1243.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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Stellate Cell Growth Medium MD-0014