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Human Neural Stem Cells (iPSC-derived, ALS)

Human Neural Stem Cells (iPSC-derived, ALS)

Catalog Number: 40HU-007
Availability: In Stock
Price: $699.00

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Product Description

Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the main phenotype of the nervous system. They primarily differentiate into neurons, astrocytes, and oligodendrocytes [1]. The recent discovery of induced pluripotent stem cells (iPSCs) not only overcomes the ethical and logistical issues associated with human embryonic stem cells, but also provides a flexible platform for generating various differentiated cell types from diseased individuals. iPSC-derived NSCs are a potentially valuable source of in vitro models for complex, polygenic human diseases, and are potentially useful for drug discovery and cell-based therapy applications [2].

iXCells Biotechnologies provides high quality human neural stem cells (NSCs) derived from normal or diseased iPS cell lines. These cells express typical markers of neural stem and progenitor cells, e.g. Nestin, Pax6 and Sox1 (Figure 1 and Figure 2), with the purity higher than 97% (Figure 3). The cells have been fully characterized for their self-renewal and multi-potency. The iPSC-derived NSCs can be differentiated into astrocytes or motor neurons (Figure 4) using our proprietary Motor Neuron Differentiation Kit (Cat# MD-0031).

All the cells provided by iXCells are negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C. The basic donor  information (gender / age / race) is provided for each cell lot purchased.

iPSC-derived neural stem cells

Figure 1.  iPSC-derived NSCs express Nestin and Pax6. 

iPSC-derived neural stem cells

Figure 2.  iPSC-derived NSCs express Nestin and Sox1. 

Figure 3.  More than 97% of the NSCs are Nestin positive. 

Figure 4.  iPSC-derived NSCs can be differentiated into GFAP+ astrocyte (A) or HB9+motor neurons (B).

Product Details

  Tissue

  Human Neural Stem Cells Derived from iPSCs (Normal, Amyotrophic Lateral Sclerosis, Parkinson’s disease, Alzheimer’s disease)

  Package Size

  2 million cells/vial  

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Human Neural Progenitor Cell Growth Medium (Cat# MD-0024)

  Motor Neuron Differentiation Kit (Cat# MD-0031)

References

[1] Alenzi, F; Bahkali, A (2011). "Stem cells: Biology and clinical potential". African Journal of Biotechnology 10 (86): 19929–40. 

[2] Dolmetsch R, Geschwind DH. (2011) “The human brain in a dish: the promise of iPSC-derived neurons”. Cell. 145(6):831-4.

 Download Datasheet

[1] Alenzi, F; Bahkali, A (2011). "Stem cells: Biology and clinical potential". African Journal of Biotechnology 10 (86): 19929–40. 

[2] Dolmetsch R, Geschwind DH. (2011) “The human brain in a dish: the promise of iPSC-derived neurons”. Cell. 145(6):831-4.

This product is intended for laboratory research purposes only. It is not intended for use in humans. While iXCells Biotechnologies uses reasonable efforts to include accurate and up-to-date information on this product sheet, we makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. iXCells Biotechnologies does not warrant that such information has been confirmed to be accurate.

This product is sent with the condition that you are responsible for its safe storage, handling, and use. iXCells Biotechnologies is not liable for any damages or injuries arising from receipt and/or use of this product. While reasonable effort is made to insure authenticity and reliability of strains on deposit, iXCells Biotechnologies is not liable for damages arising from the misidentification or misrepresentation of cultures.

© iXCells Biotechnologies 2015. All rights reserved.

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