Adipose Tissue Derived Cells
||10HU-001||Human Adipose Derived Stem Cells (hADSCs, Normal)||Mouse
||10MU-006||Mouse Adipose-Derived Stem Cells (mADSCs, from white fat)|
|10HU-025||Human Stromal Vascular Fraction (SVF, from adipose tissue)||10MU-005||Mouse Adipose-Derived Stem Cells (mADSCs, from brown fat)|
|10MU-106||Mouse Preadipocytes (mPAds, from white fat)|
||10HU-222||Human Adipose Derived Stem Cells (ADSCs, Type 1 Diabetes)||10MU-105||Mouse Preadipocytes (mPAds, from brown fat)|
|10HU-007||Human Adipose Derived Stem Cells (hADSCs, Type 2 Diabetes)||10MU-009||Mouse Stromal Vascular Fraction (SVF, from white fat)|
|10HU-232||Human Adipose Derived Stem Cells (ADSCs, Obesity)||10MU-008||Mouse Stromal Vascular Fraction (SVF, from brown fat)|
||10RA-001||Rat Adipose Derived Stem Cells (rADSCs, from white fat)|
|10RA-002||Rat Adipose Derived Stem Cells (rADSCs, from brown fat)|
Figure 1. Relationships between SVCs, ADSCs, committed preadipocytes, and mature adipocytes.
Stromal Vascular Fraction (SVF)
Stromal Vascular Fraction (SVF) is isolated from adipose tissue (white fat or brown fat), which composed of very crude and heterogeneous mix of multiple cell populations with different degree of maturity and function (Figure 2).
Figure 2. CD45, CD31 and CD29/CD34 flow result of mouse SVF (white fat).
Adipose-Derived Stem Cells (ADSCs)
It has been shown that the ADSCs demonstrate very similar phenotypic and functional characteristics to that of bone marrow-derived mesenchymal stem cells. ADSCs are also known as adipose-derived mesenchymal stem cells (AD-MSCs), adipose MSCs (AMSCs), adipose-derived adult stem (ADAS) cells, and adipose stromal/stem cells (ASCs). iXCells ADSCs are positive for CD29, CD44, CD73, CD90, CD105, and negative for CD14, CD31, CD45 (Figure 3). Normal human ADSCs have been reported to differentiate into many different lineage including chondrogenic, adipogenic (Figure 4), osteogenic (Figure 5), and neural lineages.
Figure 3. Immunostaining of human ADSCs surface markers.
Figure 4. Human ADSC adipocyte differentiation (Day 14).
Figure 5. Human ADSC osteogenic induction (Day 24).
|MD-0003||Adipose-Derived Stem Cell Growth Medium|
|MD-0005||Adipocyte Differentiation Medium|
|MD-0006||Osteogenic differentiation Medium|
|MD-0002||Adipose Derived Stem Cell Attachment Medium|
|MD-0004||Preadipocyte Growth Medium|
 William P. Cawthorn et al. (2011). “Adipose tissue stem cells meet preadipocyte commitment: going back to the future” J. Lipid Res. 53:227-246
 Kershaw EE, Flier JS; Flier (2004). "Adipose tissue as an endocrine organ". J. Clin. Endocrinol. Metab. 89 (6): 2548–56.