Human Aortic Endothelial Cells (HAOEC)

Product Description

Human Aortic Endothelial Cells (HAOEC) line the vessel wall of aorta, the largest artery in the human body. Because HAOECs are constantly exposed to high hemodynamic forces, they produce endothelium-derived substances regulating vasoconstriction and vessel growth ^[1]. HAOEC also modulate the expression of cellular adhesion molecules to control and fine-tune inflammatory responses and fibrinolysis ^[2]. These physiological properties allow HAOEC cultures to be widely used in the study of mechanisms for endothelium dysfunction, pathogenesis of vascular diseases and atherosclerosis, and the development of novel disease treatments.

iXCells Biotechnologies provides high quality HAOEC, which are isolated from human aorta and cryopreserved at P2, with >0.5 million cells in each vial. These HAOEC express vWF/Factor VIII and CD31 (Figure 1). They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand in Endothelial Cell Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies.

Figure 1.  iXCells HAOECs are positive for vVF and CD31. 

Product Details

References

1. Ando J, and Kamiya A. Flow-dependent regulation of gene expression in vascular endothelial cells. Heart J. 1996; 37:19-32.
2. Kim M, and Lee YJ. The effect of oxidized low-density lipoprotein (ox-LDL) on radiation-induced endothelial-to-mesenchymal transition. Int J Radiat Biol. 2013; 89(5):356-363.

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