Human Ovarian Surface Epithelial Cells (HOSEpC)

Product Description

The ovary is covered by a single layer of surface epithelial cells (HOSEpC) where in vivo morphology varies from squamous to cuboidal to low columnar. HOSEpC actively participate in cyclical ovulatory follicular rupture and the subsequent repair [1]. HOSEpC express a variety of peptide hormones, sex steroids, growth factors, and receptors. Many of these biological agents have been implicated in the development of epithelial ovarian carcinomas [2] and sexually transmitted infections (ivermectin) [3]. Understanding aberrations in the corresponding cellular pathways is of great clinical importance as they provide useful information regarding HOSEpC cell survival, apoptosis, transformation, and function during disease development and potential markers for disease treatment.

iXCells Biotechnologies provides high quality HOSEpC, which are isolated from human ovary and cryopreserved at P1, with >0.5 million cells in each vial. HOSEpC express cytokeratine-14, -18, and -19. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand in ​Epithelial Cell Growth Medium (Cat# MD-0041) under the condition suggested by iXCells Biotechnologies.

Product Details

References

[1]. Murdoch WJ. (1995) Endothelial cell death in preovulatory ovine follicles: possible implication in the biomechanics of rupture. J Reprod Fertil 1995; 105:161-164. 
[2]. Katabuchi H, Okamura H. (2003) Cell biology of human ovarian surface epithelial cells and ovarian carcinogenesis. Medical Electron Microscopy 36(2):74-86.

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