Human Renal Fibroblasts

Description Product Code Price Quantity Add to Cart
Cryopreserved, 0.5 million cells/vial
10HU-238
$593.00

Product Description

Fibroblasts and myofibroblasts are believed to be the key effector cells in renal fibrogenesis responsible for the synthesis and deposition of extracellular matrix components [1]. Although fibroblasts are histologically visible in normal kidneys, there are relatively few of them and proximal tubular epithelial cells predominate. In progressive disease, however, the interstitium becomes filled with myofibroblasts [2]. Fibroblasts are considered the primary matrix-producing cells in the kidney and hence they are clinically relevant as principal mediators of renal fibrosis associated with progressive renal failure [3].

iXCells Biotechnologies provides high quality Human Renal Fibroblasts, which are isolated from adult human lung tissue and cryopreserved at P1, with >0.5 million cells in each vial. Human Renal Fibroblasts express fibronectin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand no more than 3 passages in Fibroblast Growth Medium (Cat# MD-0011) under the condition suggested by iXCells Biotechnologies.

 

Human Renal Fibroblasts

Figure 1. Human Renal Fibroblasts. (A) Phase contrast image. (B) Immunofluorescence staining with antibodies against Vimentin.

 

Product Details

  Tissue

  Normal human kidney tissue

  Package Size

  0.5 million cells/vial

  Passage Number

  P1

  Shipped

  Cryopreserved 

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Fibroblast Growth Medium (Cat# MD-0011)

 

Reference

[1] Soma Meran and Robert Steadman (2011) “Fibroblasts and myofibroblasts in renal fibrosis”. Int. J. Exp. Path. 92: 158–167

[2] H. Terence Cook. (2010) “The Origin of Renal Fibroblasts and Progression of Kidney Disease”. The American Journal of Pathology, 176 (1):22-24.

[3] Frank Strutz and Michael Zeisberg. (2002) “Renal Fibroblasts and Myofibroblasts in Chronic Kidney Disease”. JASN, 17: 2992-2998.

 

 Download Datasheet

[1] Soma Meran and Robert Steadman (2011) “Fibroblasts and myofibroblasts in renal fibrosis”. Int. J. Exp. Path. 92: 158–167

[2] H. Terence Cook. (2010) “The Origin of Renal Fibroblasts and Progression of Kidney Disease”. The American Journal of Pathology, 176 (1):22-24.

[3] Frank Strutz and Michael Zeisberg. (2002) “Renal Fibroblasts and Myofibroblasts in Chronic Kidney Disease”. JASN, 17: 2992-2998.

Biological
Species Homo sapiens