Human Umbilical Vein Endothelial Cells (HUVEC)

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Cryopreserved, 0.5 million cells/vial

Product Description

Human umbilical vein endothelial cells (HUVECs) are cells derived from the endothelium of veins from the umbilical cord. They are used as a laboratory model system for the study of the function and pathology of endothelial cells (e.g., angiogenesis) [1]. They are used due to their low cost, and simple techniques for isolating them from umbilical cords, which are normally resected after childbirth [2]. HUVECs can be easily made to proliferate in a laboratory setting. They exhibit a cobblestone phenotype when lining vessel walls.

iXCells Biotechnologies provides high quality Human Umbilical Vein Endothelial Cells (HUVEC), which are isolated from human umbilical vein of mix donors, and cryopreserved at P2, with >0.5 million cells in each vial. HUVEC have “cobblestone” morphology and positive staining with vWF/Factor VIII and CD31. HUVEC are one of the mostly used cell types to study endothelial function in vitro, including angiogenesis [1], signaling pathway under normal and pathological condition such as oxidative stress, hypoxia [2] and inflammation etc. These HUVEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi and can further expand no more than 3 passages in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies. Additional expansion may decrease the purity.


Human Umbilical Vein Endothelial Cells

Figure 1. Human Umbilical Vein Endothelial Cells (HUVEC). (A) Phase contrast image of HUVEC. (B & C) Immunofluorescence staining with antibodies against vWF (B) and CD31 (C).


Product Details


  Human umbilical cord tissue

  Package Size

  0.5x106 cells/vial  

  Passage Number





  Liquid nitrogen

  Growth Properties



  Endothelial Cell Growth Medium (Cat# MD-0010)



[1]  Park HJ, Zhang Y, Georgescu SP, Johnson KL, Kong D, Galper JB (2006). "Human umbilical vein endothelial cells and human dermal microvascular endothelial cells offer new insights into the relationship between lipid metabolism and angiogenesis". Stem Cell Rev 2 (2): 93–102.

[2]  Nallamshetty S, Chan SY, and Loscalzo J. Hypoxia: a master regulator of microRNA biogenesis and activity. Free Radic Biol Med. 2013; 64: 20-30.


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  • Hunt, R. C., Katneni, U., Yalamanoglu, A., Indig, F. E., Ibla, J. C., & Kimchi‐Sarfaty, C. (2022). Contribution of adamts13 ‐independent vwf regulation in sickle cell disease. Journal of Thrombosis and Haemostasis. -- Learn More

  • Laiva, A. L., O’Brien, F. J., & Keogh, M. B. (2021). SDF-1α Gene-Activated Collagen Scaffold RESTORES pro-angiogenic wound HEALING features in Human Diabetic Adipose-derived stem cells. Biomedicines, 9(2), 160. doi:10.3390/biomedicines9020160 -- Learn More

  • Shen, L., Hu, Y., Lou, J., Yin, S., Wang, W., Wang, Y., . . . Wu, W. (2019). CircRNA‑0044073 is upregulated in atherosclerosis and increases the proliferation and invasion of cells by TARGETING MIR‑107. Molecular Medicine Reports. doi:10.3892/mmr.2019.10011 -- Learn More

Cell System Umbilical Cord Cell System
Cell System Vascular Cell System
Cell Type Endothelial Cells
Species Human (Normal)



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