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Genome Editing Services

Customized genome editing services using CRISPR/Cas9 technology for SNP replacement, large reporter gene knock-in, and DNA knock-out in iPSC and other cell lines.

Gene Editing solutions

We Accelerate your research with our comprehensive genome editing services. Our expert team utilizes CRISPR/Cas9 technology to tailor genome editing to your specific requirements. Whether you require permanent knock-out, conditional knock-out, point mutation, or insertion, we have you covered.

GE Service Capabilities

Types of Gene Editing
  • CRISPR/Cas9
Types of Cells
  • Stem cells
  • Non-stem cell lines
Types of Services
  • Knock-in
    Reporters, exon duplication, overexpression, safe harbor sites etc.
  • Knock-out
    Frameshift, stop codon, fragment deletion
  • Point mutation
    Single nucleotide mutation, small fragment replacement

Special Designs for KI and KO

Knock-in
  • KI at safe harbor sites
  • Duplication of Exons
  • Luciferase, fluorescence marker and label tags KI for different genes
Knock-out
  • KO by frame shift
  • KO by introducing stop codon
  • KO by large fragment deletion

Our services are compatible with both in-house iPSC lines and custom-provided cell lines. If you choose cell lines derived from patients, rest assured that they have undergone thorough testing for Mycoplasma, HIV, Hepatitis B, and C, ensuring their quality and safety.

TALK TO CRISPR EXPERTS

Why Choose Us

We offer efficient and effortless end-to-end services. We handle cell reprogramming and gene editing, allowing you to focus on your research while we optimize the process, taking the burden off your shoulders.

Highly Efficient Technologies ​

Different Gene Editing Types
  • Knock-in, Knock-out, Point Mutation
  • Homozygous, Heterozygous

Single Cell Cloning

Automated Processes for Consistency

Fast Turnaround: 3-4 months

High Success Rate: >95%
Comprehensive QC
  • Cell viability and morphology
  • iPSC characterization
  • Sanger sequencing confirmation
  • Mycoplasma test
  • Functional assays, qPCR and WB etc.
  • Off-target verification

Genome Editing Workflow

READY TO MOVE FORWARD TOGETHER? GET A FREE QUOTE

CRISPR Engineered Cells

We offer a range of ready-to-use CRISPR-engineered cells for various disease models.

  • Readily Available Disease Models. Shop Now
  • Seamless Integration: Receive engineered cells with your desired gene knockout or knock-in sequence, ready for seamless integration into your application.
  • Accelerate Research: Utilize our cells for disease modeling, target identification and validation, uncovering gene function, and accelerating scientific discoveries. You can also provide your proprietary cell line for our scientific team to gene edit according to your specifications.
  • Empower Research. Utilize patient relevant isogenic cell lines custom produced by iXCells as controls for studying diseases enabling you to examine effects of a mutation within a fixed genetic background.

DISCOVER OUR PRODUCTS & ADDITIONAL SERVICES

iPSC DIFFERENTIATION SERVICES

Established differentiation and marker staining protocols for a wide range of cell types, ensuring reliable and consistent results every time.

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iPS CELL GENERATION

Drug discovery, drug screening, disease modeling, personalized medicine, and preclinical cell regeneration projects. Our approach allows us to develop tailored solutions that address your unique needs and accelerate the path to success.

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CUSTOM CELL ISOLATION

Customized cell isolation services with an extensive network of ethically procured tissues from donors with specific requirements. Available in a variety of formats and can be obtained from a wide range of species and diseases.

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Frequently Asked Questions (FAQs)

  • Cells to be edited: Two vials of frozen stocks on dry ice or one T25 flask of live cells per sample. The cells have to be actively dividing cells. Non-dividing cells or slow-proliferating cells are not able to be edited. iXCells also provides a wide collection of primary cells/iPSCs (link) for the customers to choose from.
  • Recipe of the culture media.
  • Culture protocol.
  • Pathogen screening data.
  • Transfection protocol if available.

It takes 2-5 months depending on the recovery of the cells provided by the customer, the proliferation rate and transfection efficiency of the cells, and validation assays requested by the customer.

We will ship 3 frozen vials of each clone to the customer. Live cultures are available upon requests. We will also provide final report in publication-ready format.

We will provide 1) the gene editing method we used to edit the cell line; 2) the recovery and maintenance method after you receive the cells; 3) Cell recovery and live culture delivery if desired; 4) in-house training course if desired.