Human Neural Stem Cells (iPSC-derived, Normal)

Description Product Code Price Quantity Add to Cart
Cryopreserved, 2.0 million cells/vial
40HU-001
$709.00

Product Description

Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the main phenotype of the nervous system. They primarily differentiate into neurons, astrocytes, and oligodendrocytes [1]. The recent discovery of induced pluripotent stem cells (iPSCs) not only overcomes the ethical and logistical issues associated with human embryonic stem cells, but also provides a flexible platform for generating various differentiated cell types from diseased individuals. iPSC-derived NSCs are a potentially valuable source of in vitro models for complex, polygenic human diseases, and are potentially useful for drug discovery and cell-based therapy applications [2].

iXCells Biotechnologies provides high quality human neural stem cells (NSCs) derived from normal or diseased iPS cell lines. These cells express typical markers of neural stem and progenitor cells, e.g. Nestin, Pax6 and Sox1 (Figure 1 and Figure 2), with the purity higher than 97% (Figure 3). The cells have been fully characterized for their self-renewal and multi-potency. The iPSC-derived NSCs can be differentiated into astrocytes or motor neurons (Figure 4) using our proprietary Motor Neuron Differentiation Kit (Cat# MD-0031).

All the cells provided by iXCells are negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C. The basic donor  information (gender / age / race) is provided for each cell lot purchased.

iPSC-derived neural stem cells

Figure 1.  iPSC-derived NSCs express Nestin and Pax6. 

iPSC-derived neural stem cells

Figure 2.  iPSC-derived NSCs express Nestin and Sox1. 

Figure 3.  More than 97% of the NSCs are Nestin positive. 

Figure 4.  iPSC-derived NSCs can be differentiated into GFAP+ astrocyte (A) or HB9+motor neurons (B).

Product Details

  Tissue

  Human Neural Stem Cells Derived from iPSCs (Normal, Amyotrophic Lateral Sclerosis, Parkinson’s disease, Alzheimer’s disease)

  Package Size

  2 million cells/vial  

  Shipped

  Cryopreserved

  Storage

  Liquid nitrogen

  Growth Properties

  Adherent

  Media

  Human Neural Progenitor Cell Growth Medium (Cat# MD-0024)

  Motor Neuron Differentiation Kit (Cat# MD-0031)

 

References

[1] Alenzi, F; Bahkali, A (2011). "Stem cells: Biology and clinical potential". African Journal of Biotechnology 10 (86): 19929–40. 

[2] Dolmetsch R, Geschwind DH. (2011) “The human brain in a dish: the promise of iPSC-derived neurons”. Cell. 145(6):831-4.

 Download Datasheet

[1] Alenzi, F; Bahkali, A (2011). "Stem cells: Biology and clinical potential". African Journal of Biotechnology 10 (86): 19929–40. 

[2] Dolmetsch R, Geschwind DH. (2011) “The human brain in a dish: the promise of iPSC-derived neurons”. Cell. 145(6):831-4.

Biological
Species Human (Normal)