Human iPS Cell Line (Normal)

Description Product Code Price Quantity Add to Cart
Cryopreserved, 0.5-1.0 million cells/vial
30HU-002
$1,510.00

Product Description

Induced Pluripotent Stem Cells (iPSCs) are a type of stem cells reprogrammed from a multitude of somatic cells into an embryonic like pluripotent state. They have large self-renewal capability and can differentiate into any cell type from all three germ layers [1, 2]. Due to their high differentiation potential, iPSCs emerge as a promising cell model to promote cell differentiation for the regeneration studies. Importantly, iPSCs reprogrammed from rare disease carriers can be subsequently expanded and differentiated indefinitely, allowing for genetically pertinent disease-specific iPSC model for research [3]. iPS cells, thus, are a unique model for studying a variety of processes that occur in the early development of mammals and are a promising tool in cell therapy of human diseases [4].

iXCells Biotechnologies is proud to offer human iPSCs derived from normal and patient somatic cells (dermal fibroblasts, adipose-derived stem cells, peripheral blood mononuclear cells) with different race, gender, and age options to choose from. The pertinent donor information is available on the CoA or upon request (This email address is being protected from spambots. You need JavaScript enabled to view it.).

These iPSCs are established from a single clone and expanded in feeder-free conditions. iXCell’s iPSCs demonstrate hESC morphology, express pluripotency markers, have normal karyotype, and are integration free. They are negative for mycoplasma, bacteria, yeast, fungi, HIV-1, HBV and HCV.

30HU 002 description image2

Figure 1. iXCells human iPS cells are characterized by immunostaining with Oct4, Nanog, TRA-1-60-R, TRA-1-81(Green).

In addition, patient-derived iPS cell lines are also available as separate product. The currently available disease specific iPS cell lines are derived from patients with Type 2 Diabetes (T2D), Alzheimers's Disease (AD), Parkinson's Disease (PD), Amyotrophic Lateral Sclerosis (ALS). More disease-specific iPS lines are under development. We also provide custom iPSC generation and iPSC differentiation services to meet your needs.

 

Product Details

Tissue Origin

Human iPS Cells derived from dermal fibroblasts, adipose-derived stem cells, or peripheral blood mononuclear cells

Package Size

~0.5-1.0 million cells/vial

Shipped

Cryopreserved

Storage

Liquid nitrogen

Growth Properties

Adherent

Media & Reagents

Human iPSC Feeder-Free Growth Medium (Cat # MD-0019)

Human iPSC Xeno-Free Growth Medium (Cat # MD-0074)

 

Download Datasheet

References

[1] Medvedev, S. P., Shevchenko, A. I., & Zakian, S. M. (2010). Induced Pluripotent Stem Cells: Problems and Advantages when Applying them in Regenerative Medicine. Acta naturae, 2(2), 18–28.

[2] Ghaedi, M., & Niklason, L. E. (2019). Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells. Methods in molecular biology (Clifton, N.J.), 1576, 55–92.

[3] Okita, K., Matsumura, Y., Sato, Y., Okada, A., Morizane, A., Okamoto, S., Hong, H., Nakagawa, M., Tanabe, K., Tezuka, K., Shibata, T., Kunisada, T., Takahashi, M., Takahashi, J., Saji, H., & Yamanaka, S. (2011). A more efficient method to generate integration-free human iPS cells. Nature methods, 8(5), 409–412

[4] Ebert, A. D., Liang, P., & Wu, J. C. (2012). Induced pluripotent stem cells as a disease modeling and drug screening platform. Journal of cardiovascular pharmacology, 60(4), 408–416.

  • Dong, X., Chen, Y., Lu, J., Huang, S., & Pei, G. (2022). Β-arrestin 2 and EPAC2 cooperatively mediate DRD1-stimulated proliferation of human neural stem cells and growth of human cerebral organoids. Stem Cells. https://doi.org/10.1093/stmcls/sxac046 -- Learn More

  • Huang, M., Wang, X., Banerjee, M., Mukherji, S. T., Kutz, L. C., Zhao, A., Sepanski, M., Fan, C.-M., Zhu, G.-Z., Tian, J., Wang, D.-Z., Zhu, H., Xie, Z.-J., Pierre, S. V., & Cai, L. (2022). Regulation of myogenesis by a na/K-atpase α1 caveolin binding motif. Stem Cells. https://doi.org/10.1093/stmcls/sxab012 -- Learn More

  • Huang, S., Huang, F., Zhang, H., Yang, Y., Lu, J., Chen, J., Shen, L., & Pei, G. (2022). In vivo development and single‐cell transcriptome profiling of human brain organoids. Cell Proliferation. https://doi.org/10.1111/cpr.13201 -- Learn More
  • Wang, X., Cai, L., Xie, J. X., Cui, X., Zhang, J., Wang, J., . . . Xie, Z. (2020). A caveolin Binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals andc.elegans. Science Advances, 6(22). doi:10.1126/sciadv.aaw5851 -- Learn More

  • Hilary Sherman & Hannah J. Gitschier. (2019). A Novel Method for Generating Single, Intestinal Organoids for High Throughput Screening. Corning Application Note -- Learn More
  • Gasset-Rosa, F., Lu, S., Yu, H., Chen, C., Melamed, Z., Guo, L., . . . Cleveland, D. W. (2019). Cytoplasmic TDP-43 De-mixing independent of Stress Granules Drives inhibition of NUCLEAR IMPORT, loss of Nuclear TDP-43, and cell death. Neuron, 102(2). doi:10.1016/j.neuron.2019.02.038 -- Learn More

  • Gao, X., Sprando, R. L., & Yourick, J. J. (2018). A rapid and highly efficient method for the Isolation, purification, and Passaging of Human-Induced pluripotent stem cells. Cellular Reprogramming, 20(5), 282-288. doi:10.1089/cell.2018.0022 -- Learn More

  • Marei, H. E., Althani, A., Lashen, S., Cenciarelli, C., & Hasan, A. (2017). Genetically unmatched human Ipsc and Esc Exhibit Equivalent gene expression and neuronal differentiation potential. Scientific Reports, 7(1). doi:10.1038/s41598-017-17882-1 -- Learn More
  • Gao, X., Yourick, J. J., & Sprando, R. L. (2017). Comparative transcriptomic analysis of endothelial progenitor cells derived from umbilical cord blood and adult peripheral blood: Implications for the generation of induced pluripotent stem cells. Stem Cell Research, 25, 202-212. doi:10.1016/j.scr.2017.11.004 -- Learn More

Biological
Species Homo sapiens

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