Mouse Aortic Endothelial Cells (MAOEC)

Product Description

Mouse Aortic Endothelial Cells (MAOEC) line the vessel wall of aorta and are constantly exposed to high hemodynamic forces. They produce endothelium-derived substances regulating vasoconstriction and vessel growth ^[1]. MAOEC also modulate the expression of cellular adhesion molecules to control and fine-tune inflammatory responses and fibrinolysis ^[2]. These physiological properties allow MAOEC cultures to be widely used in the study of mechanisms for endothelium dysfunction, pathogenesis of vascular diseases and atherosclerosis, and the development of novel disease treatments.

iXCells Biotechnologies provides high quality Mouse Aortic Endothelial Cells (MAOEC), which are isolated mouse aorta and cryopreserved at P2, with ≥ 0.5 million cells in each vial. MAOEC express vWF/Factor VIII, CD31 (PECAM) and DiI-Ac-LDL by uptake. These MAOEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for no more than 3 passages in Endothelial Cell Growth Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies. Further expansion may decrease the purity.

Figure 1. Mouse aortic endothelial cells (MAOEC).  (A) Phase contrast image of MAOEC. (B) Immunofluorescence staining with antibody against CD31 and Tie-2.

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[1]  Ando J, and Kamiya A. Flow-dependent regulation of gene expression in vascular endothelial cells. Heart J. 1996; 37:19-32.

[2]  Nishiyama T, et al and Saito I. Functional analysis of an established mouse vascular endothelial cell line. J Vasc Res. 2007;44(2):138-148