Mouse Skeletal Muscle Satellite Cells (MSkMSC)

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Product Description

Skeletal muscle contains both differentiated myofibers and stem cells, known as satellite cells. The satellite cells, comprising around 1% of the total muscle nuclei, are situated between the plasma membrane of the multinucleated muscle cells and the basal lamina that surrounds each myofiber. In adult muscle, satellite cells are quiescent but proliferate in response to muscle injury, producing myoblasts that can either form new satellite cells or fuse with one another or pre-existing multinucleated muscle cells to help repair the muscle. They are responsible for postnatal muscle growth, hypertrophy and regeneration of skeletal muscle ^[1]. When quiescent satellite cells are activated, they co-express the transcription factors Pax7 and myoD ^[2].

Mouse Skeletal Muscle Satellite Cells (MSkMSC) from iXCells are isolated from mouse muscle of the pectoral girdle. MSkMSC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10^5 cells in 1 ml volume. MSkMSC are characterized by immunofluorescence with antibodies specific to myosin, actin and actinin. MSkMSC are negative for mycoplasma, bacteria, yeast and fungi. MSkMSC are guaranteed to further expand for 15 population doublings using the culture medium provided by iXCells.

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