Rat Sertoli Cells (RSC)

Product Description

Sertoli cells are highly specialized cells found in the testes. They played an important role in the development and maturation of sperm cells, or spermatozoa, within the testes, a process called spermatogenesis. Because Sertoli cells function largely to assist the developing sperm cells through their maturation process, they sometimes are referred to as a nurse cell of the testicles. They are part of a seminiferous tubule and helps in the process of spermatogenesis ^[1]. Sertoli cells provide immature models for a high potential of nursing purpose and supporting function for the maturity.

iXCells Biotechnologies provides high quality Rat Sertoli Cells (RSC), which are isolated from the testes of male rats aged 19-21 days and cryopreserved at P0, with >1 million cells in each vial. RSC express Vimentin and they are negative for mycoplasma, bacteria, yeast, and fungi. RSCs can be maintained in Sertoli Cell Growth Medium (Cat# MD-0091) under the condition suggested by iXCells Biotechnologies.    

Figure 1: (A) Phase contrast image of Rat Sertoli Cells (RSC) taken at 7 days post recovery. (B) RSC are positive for Vimentin as shown by immunofluorescence staining.

Product Details

References

[1] Chui K, Trivedi A, Cheng C, Cherbavaz, Dazin P, Huynh A, Mitchell J, Rabinovich G, Noble-Haeusslein L, John C. (2011) "Characterization and functionality of proliferative human Sertoli cells." Cell Transplant. 20(5): 619-635.

[2] Sharpe R, McKinnell C, Kivlin C, Fisher J. (2003) "Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood." Reproduction. 125: 769-784.

[3] Tarulli G, Stanton P, Meachem S. (2012) "Is the adult Sertoli cell terminally differentiated" Biol Reprod. 87(1): 1-11.

[3] Burgess, M. L., Terracio, L, Hirozane, T., Borg, T. K. (2002) “Differential integrin expression by cardiac fibroblasts from hypertensive and exercise-trained rat hearts. Cardiovasc Pathol 11(2):78-87.

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