Endostatin, Human

Description Product Code Price Quantity Add to Cart
20ug
IX02533-20
$39.00
100ug
IX02533-100
$95.00

Overview

Synonyms Endostatin;
Description Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. Recombinant Endostatin expressed in yeast, whichcauses G1 arrest of endothelial cells. Endostatin treatment results in apoptosis of HUVE and HMVE cells. Recombinant human Endostatin is a 20.2 kDa protein consisting of 184 amino acid residues.
Species Human
Source P. pastoris
Biological Activity Determined by Endothelial Cell Tube Formation. The cells treated with 10μg/ml Endostatin showed significant anti-angiogenesis effect.
Sequence
AHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA
VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL
FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV
WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG
QSAASCHHAY IVLCIENSFM TASK

Properties

Purity Greater than 97% by SDS-PAGE
Formulation The sterile filtered solution was lyophilized with 17 mM citric-phosphate buffer, pH 6.2.
Endotoxin Level Endotoxin level is less than 0.1 ng per μg (1EU/μg) of Endostatin.
Storage The lyophilized Endostatin is stable for a few weeks at room temperature, but best stored at -20°C. For the first use, reconstitute in water, aliquot and store at -20°C to avoid multiple freeze-thaws.
Note ;
Biological
Source P. pastoris
Species Human