Eotaxin/CCL11, Mouse
| Description | Product Code | Price | Quantity | Add to Cart |
|---|---|---|---|---|
|
20ug
|
IX02902-20
|
$159.00
|
||
|
1mg
|
IX02902-1
|
$2,100.00
|
Overview
| Synonyms | Eotaxin murine; CCL11 murine |
| Description | Eotaxin also called CCL11 is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions. |
| Species | Mouse |
| Source | E. coli |
| Biological Activity | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using purified eosinophils is in a concentration range of 100-1000 ng/ml. |
| Sequence | HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP |
Properties
| Measured Molecular Weight | Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids. |
| Purity | > 96 % by SDS-PAGE and HPLC analyses. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| Endotoxin Level | Less than 1 EU/μg of rMuEotaxin/CCL11 as determined by LAL method. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Storage | This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles. |
| Note | ; |
| Biological | |
|---|---|
| Source | E. coli |
| Species | Mouse |