Eotaxin/CCL11, Mouse
Description | Product Code | Price | Quantity | Add to Cart |
---|---|---|---|---|
20ug
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IX02902-20
|
$159.00
|
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1mg
|
IX02902-1
|
$2,100.00
|
Overview
Synonyms | Eotaxin murine; CCL11 murine |
Description | Eotaxin also called CCL11 is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions. |
Species | Mouse |
Source | E. coli |
Biological Activity | Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using purified eosinophils is in a concentration range of 100-1000 ng/ml. |
Sequence | HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP |
Properties
Measured Molecular Weight | Approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids. |
Purity | > 96 % by SDS-PAGE and HPLC analyses. |
Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
Endotoxin Level | Less than 1 EU/μg of rMuEotaxin/CCL11 as determined by LAL method. |
Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
Storage | This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles. |
Note | ; |
Biological | |
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Source | E. coli |
Species | Mouse |