Human Coronary Artery Endothelial Cells (HCAECs)

Description

Product Description

Human Coronary Artery Endothelial Cells (HCAECs) line the vessel wall of coronary artery. They are extremely important in regulation of coronary blood flow and cardiac function. HCAEC has been used as a valuable in vitro model system to study the cardiovascular diseases such as thrombosis, atherosclerosis, hypertension, coronary artery diseases ^[1] and diabetes-related cardiovascular diseases ^[2].

iXCells Biotechnologies provides high quality HCAECs, which are isolated from human coronary artery from single donors and cryopreserved at P2, with ≥ 0.5 million cells in each vial. These HCAECs express vWF/Factor VIII, VE-Cadherin, and CD31. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand no more than 3 passages in Endothelial Cell Medium (Cat# MD-0010) under the condition suggested by iXCells Biotechnologies.

Figure 1. (A) HCAEC Phase contract (B) HCAEC CD31 staining (C)HCAEC vWF staining

 

Product Details

Tissue	Human coronary artery
Package Size	0.5 millioncells/vial
Passage Number	P2
Shipped	Cryopreserved
Storage	Liquid nitrogen
Growth Properties	Adherent
Media	Endothelial Cell Medium Kit (Cat# MD-0010)

 

References

[1] Besler C,et al and Landmesser U. Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. J Clin Invest. 2011; 121 (7): 2693-2708.

[2] Eriksson L and Nystrom T. Activation of AMP-activated protein kinase by metformin protects human coronary artery endothelial cells against diabetic lipoapoptosis. Cardiovasc Diabetol. 2014; 13:152

 

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